Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

Coordinated regulation of the ubiquitin-proteasome system (UPS) is crucial for the cell to adjust its protein degradation capacity to changing proteolytic requirements. We have shown previously that mammalian cells upregulate proteasome gene expression in response to proteasome inhibition. Here, we...

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Veröffentlicht in:	Molecular cell 2010-10, Vol.40 (1), p.147-158
Hauptverfasser:	Steffen, Janos, Seeger, Michael, Koch, Annett, Krüger, Elke
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Adenosine Triphosphatases - metabolism Amino Acid Sequence Antioxidants - metabolism ATPases Associated with Diverse Cellular Activities Cell Line Endoplasmic Reticulum - metabolism Endothelial Cells - drug effects Endothelial Cells - enzymology Feedback, Physiological Gene Expression Regulation Homeostasis Humans Molecular Sequence Data NF-E2-Related Factor 1 - genetics NF-E2-Related Factor 1 - metabolism Nuclear Proteins - metabolism Oxidative Stress Protease Inhibitors - pharmacology Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - genetics Response Elements RNA Interference RNA, Messenger - metabolism Transcription, Genetic - drug effects Transfection Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination
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