Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion
Eight new palladium(II) complexes ( 1a– 2d) with 4-toluenesulfonyl- l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV, 1H NMR, 13C NMR and mass spectra techniques. Crystal structure of the complex ( 2d) has been determined by X-ray...
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| Veröffentlicht in: | European journal of medicinal chemistry 2010-11, Vol.45 (11), p.5337-5344 |
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| container_title | European journal of medicinal chemistry |
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| creator | Zhang, Jinchao Li, Luwei Wang, Liwei Zhang, Fangfang Li, Xiaoliu |
| description | Eight new palladium(II) complexes (
1a–
2d) with 4-toluenesulfonyl-
l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV,
1H NMR,
13C NMR and mass spectra techniques. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (
1a–
2d) have selectivity against tested carcinoma cell lines. The complex (
2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-
l-amino acid have important effect on cytotoxicity.
Eight palladium(II) complexes (
1a–
2d) have been synthesized. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.
[Display omitted] |
| doi_str_mv | 10.1016/j.ejmech.2010.08.058 |
| format | Article |
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1a–
2d) with 4-toluenesulfonyl-
l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV,
1H NMR,
13C NMR and mass spectra techniques. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (
1a–
2d) have selectivity against tested carcinoma cell lines. The complex (
2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-
l-amino acid have important effect on cytotoxicity.
Eight palladium(II) complexes (
1a–
2d) have been synthesized. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.
[Display omitted]</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2010.08.058</identifier><identifier>PMID: 20833452</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Amino Acids - chemistry ; Anions ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Cell Line, Tumor ; Characterization ; Cytotoxicity ; Diamines - chemical synthesis ; Diamines - chemistry ; Diamines - pharmacology ; General aspects ; Humans ; Ligands ; Magnetic Resonance Spectroscopy ; Medical sciences ; Models, Molecular ; Palladium (II) complexes ; Palladium - chemistry ; Pharmacology. Drug treatments ; Spectrophotometry, Infrared ; Synthesis</subject><ispartof>European journal of medicinal chemistry, 2010-11, Vol.45 (11), p.5337-5344</ispartof><rights>2010 Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-37b84d31898381d473ea67b74a0b1d4422b7323e8f5475dc01ed659c8c1ffaf23</citedby><cites>FETCH-LOGICAL-c391t-37b84d31898381d473ea67b74a0b1d4422b7323e8f5475dc01ed659c8c1ffaf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523410006392$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23367559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20833452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jinchao</creatorcontrib><creatorcontrib>Li, Luwei</creatorcontrib><creatorcontrib>Wang, Liwei</creatorcontrib><creatorcontrib>Zhang, Fangfang</creatorcontrib><creatorcontrib>Li, Xiaoliu</creatorcontrib><title>Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Eight new palladium(II) complexes (
1a–
2d) with 4-toluenesulfonyl-
l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV,
1H NMR,
13C NMR and mass spectra techniques. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (
1a–
2d) have selectivity against tested carcinoma cell lines. The complex (
2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-
l-amino acid have important effect on cytotoxicity.
Eight palladium(II) complexes (
1a–
2d) have been synthesized. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.
[Display omitted]</description><subject>Amino Acids - chemistry</subject><subject>Anions</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Characterization</subject><subject>Cytotoxicity</subject><subject>Diamines - chemical synthesis</subject><subject>Diamines - chemistry</subject><subject>Diamines - pharmacology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Palladium (II) complexes</subject><subject>Palladium - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrophotometry, Infrared</subject><subject>Synthesis</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2O0zAQhSMEYrsLb4BQbhCLRIp_Y_cGCa34qbQSF8C15doTOlUSF9uBhjfhbXG3Be64ssbnmzP2nKp6QsmSEtq-2i1hN4DbLhkpV0QvidT3qgVVrW44k-J-tSCM8UYyLi6qy5R2hBDZEvKwumBEcy4kW1S_Ps1j3kLC9LJ2WxutyxDxp80YxtqOvnZzDjkc0GGe69DVAx7ANz1-vRPDsO_hAOmo7G3fW4_TcL1ev6h_YN7WNoahWLnaIw44wp2jaHLoJxghTX0Xxrlv6r6xRQ61degLa8cy_VH1oLN9gsfn86r68u7t55sPze3H9-ubN7eN4yuaG642WnhO9UpzTb1QHGyrNkpYsimlYGyjOOOgOymU9I5Q8K1cOe1o19mO8avq-cl3H8O3CVI2AyYH5S8jhCkZJZVoGdNHUpxIF0NKETqzjzjYOBtKzDETszOnTMwxE0O0KZmUtqfnAdNmAP-36U8IBXh2Bmxytu-iHR2mfxznrZJyVbjXJw7KOr4jRJMcwujAYwSXjQ_4_5f8Bpu4ro4</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Zhang, Jinchao</creator><creator>Li, Luwei</creator><creator>Wang, Liwei</creator><creator>Zhang, Fangfang</creator><creator>Li, Xiaoliu</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion</title><author>Zhang, Jinchao ; Li, Luwei ; Wang, Liwei ; Zhang, Fangfang ; Li, Xiaoliu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-37b84d31898381d473ea67b74a0b1d4422b7323e8f5475dc01ed659c8c1ffaf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acids - chemistry</topic><topic>Anions</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Characterization</topic><topic>Cytotoxicity</topic><topic>Diamines - chemical synthesis</topic><topic>Diamines - chemistry</topic><topic>Diamines - pharmacology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Models, Molecular</topic><topic>Palladium (II) complexes</topic><topic>Palladium - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrophotometry, Infrared</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jinchao</creatorcontrib><creatorcontrib>Li, Luwei</creatorcontrib><creatorcontrib>Wang, Liwei</creatorcontrib><creatorcontrib>Zhang, Fangfang</creatorcontrib><creatorcontrib>Li, Xiaoliu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jinchao</au><au>Li, Luwei</au><au>Wang, Liwei</au><au>Zhang, Fangfang</au><au>Li, Xiaoliu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>45</volume><issue>11</issue><spage>5337</spage><epage>5344</epage><pages>5337-5344</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Eight new palladium(II) complexes (
1a–
2d) with 4-toluenesulfonyl-
l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV,
1H NMR,
13C NMR and mass spectra techniques. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (
1a–
2d) have selectivity against tested carcinoma cell lines. The complex (
2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-
l-amino acid have important effect on cytotoxicity.
Eight palladium(II) complexes (
1a–
2d) have been synthesized. Crystal structure of the complex (
2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.
[Display omitted]</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>20833452</pmid><doi>10.1016/j.ejmech.2010.08.058</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of medicinal chemistry, 2010-11, Vol.45 (11), p.5337-5344 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acids - chemistry Anions Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Characterization Cytotoxicity Diamines - chemical synthesis Diamines - chemistry Diamines - pharmacology General aspects Humans Ligands Magnetic Resonance Spectroscopy Medical sciences Models, Molecular Palladium (II) complexes Palladium - chemistry Pharmacology. Drug treatments Spectrophotometry, Infrared Synthesis |
| title | Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl- l-amino acid dianion |
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