Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study

To establish an LC-MS/MS method for simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of Fritillaria thunbergii Miq. extract, the pharmacokinetic parameters were calculated as well. Peimine, peiminine and internal standard carbamazepine were...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 2010-07, Vol.45 (7), p.891-894
Hauptverfasser:	Chen, Li-hua, Liu, Li-li, Liu, Hong-ning, Zhu, Wei-feng, Yi, Wen-jiao, Zhao, Yi
Format:	Artikel
Sprache:	chi
Schlagworte:	Administration, Oral Animals Cevanes - blood Cevanes - pharmacokinetics Chromatography, Liquid - methods Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacokinetics Female Fritillaria - chemistry Injections, Intravenous Plants, Medicinal - chemistry Rats Rats, Sprague-Dawley Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods
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