Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study
To establish an LC-MS/MS method for simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of Fritillaria thunbergii Miq. extract, the pharmacokinetic parameters were calculated as well. Peimine, peiminine and internal standard carbamazepine were...
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| Veröffentlicht in: | Yao hsüeh hsüeh pao 2010-07, Vol.45 (7), p.891-894 |
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| container_title | Yao hsüeh hsüeh pao |
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| creator | Chen, Li-hua Liu, Li-li Liu, Hong-ning Zhu, Wei-feng Yi, Wen-jiao Zhao, Yi |
| description | To establish an LC-MS/MS method for simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of Fritillaria thunbergii Miq. extract, the pharmacokinetic parameters were calculated as well. Peimine, peiminine and internal standard carbamazepine were extracted from plasma with liquid-liquid extraction by ethyl acetate, then separated on a Luna C18 column by using acetonitrile-water containing 10 mmol x L(-1) ammonium formate (35:65), as mobile phase. The electrospray ionization (ESI) source was applied and operated in positive ion mode. Peimine was detected at m/z 432.4 --> 414.4, peiminine at m/z 430.4 --> 412.4 and carbamazepine (IS) at 237.1 --> 194.2. The linear calibration curves were obtained at the concentration range of 0.8-800 ng x mL(-1) for peimine and peiminine. The extraction recoveries were 94.1%-105.3% and 85.8%-98.6%, respectively. The precisions, accuracy and stability of the analytes meet the requirements. The method was shown to be effective, |
| format | Article |
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Peimine, peiminine and internal standard carbamazepine were extracted from plasma with liquid-liquid extraction by ethyl acetate, then separated on a Luna C18 column by using acetonitrile-water containing 10 mmol x L(-1) ammonium formate (35:65), as mobile phase. The electrospray ionization (ESI) source was applied and operated in positive ion mode. Peimine was detected at m/z 432.4 --> 414.4, peiminine at m/z 430.4 --> 412.4 and carbamazepine (IS) at 237.1 --> 194.2. The linear calibration curves were obtained at the concentration range of 0.8-800 ng x mL(-1) for peimine and peiminine. The extraction recoveries were 94.1%-105.3% and 85.8%-98.6%, respectively. The precisions, accuracy and stability of the analytes meet the requirements. 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Peimine, peiminine and internal standard carbamazepine were extracted from plasma with liquid-liquid extraction by ethyl acetate, then separated on a Luna C18 column by using acetonitrile-water containing 10 mmol x L(-1) ammonium formate (35:65), as mobile phase. The electrospray ionization (ESI) source was applied and operated in positive ion mode. Peimine was detected at m/z 432.4 --> 414.4, peiminine at m/z 430.4 --> 412.4 and carbamazepine (IS) at 237.1 --> 194.2. The linear calibration curves were obtained at the concentration range of 0.8-800 ng x mL(-1) for peimine and peiminine. The extraction recoveries were 94.1%-105.3% and 85.8%-98.6%, respectively. The precisions, accuracy and stability of the analytes meet the requirements. The method was shown to be effective,</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Cevanes - blood</subject><subject>Cevanes - pharmacokinetics</subject><subject>Chromatography, Liquid - methods</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - pharmacokinetics</subject><subject>Female</subject><subject>Fritillaria - chemistry</subject><subject>Injections, Intravenous</subject><subject>Plants, Medicinal - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><issn>0513-4870</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAUhT2AaCn8BeSNKcKv1PaIKl5SKobCHPlxoxryMLEzdOG3E2iZ7jnSp0-65wwtSUl5IZQkC3SZ0gchgmquLtCCEc2pVGqJvnehm9psehimhD1kGLvQmxyGHg8NjhDmCtj0_pR_W-jxaDKOrUmdwfaAq02x3d1td39cyAmbGNvgjpqZznvAcW_Gzrjhczbk4HDKkz9cofPGtAmuT3eF3h8f3jbPRfX69LK5r4pIWZkLEEQzYyhrnCNeO6a44lQLy9R6zYWV1HDvtPWNBSp84xSz4CSRDgQvZcNX6PbojePwNUHKdReSg7Y9Pl7LUopS03mvFbo5kZPtwNdxDJ0ZD_X_ZPwHQrhpDA</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Chen, Li-hua</creator><creator>Liu, Li-li</creator><creator>Liu, Hong-ning</creator><creator>Zhu, Wei-feng</creator><creator>Yi, Wen-jiao</creator><creator>Zhao, Yi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study</title><author>Chen, Li-hua ; Liu, Li-li ; Liu, Hong-ning ; Zhu, Wei-feng ; Yi, Wen-jiao ; Zhao, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-e4092aa12fcc0d9c28383194b286634b71a3dc9bdfbe14dfc82bec707ce4357f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Cevanes - blood</topic><topic>Cevanes - pharmacokinetics</topic><topic>Chromatography, Liquid - methods</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - pharmacokinetics</topic><topic>Female</topic><topic>Fritillaria - chemistry</topic><topic>Injections, Intravenous</topic><topic>Plants, Medicinal - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproducibility of Results</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Li-hua</creatorcontrib><creatorcontrib>Liu, Li-li</creatorcontrib><creatorcontrib>Liu, Hong-ning</creatorcontrib><creatorcontrib>Zhu, Wei-feng</creatorcontrib><creatorcontrib>Yi, Wen-jiao</creatorcontrib><creatorcontrib>Zhao, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Yao hsüeh hsüeh pao</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Li-hua</au><au>Liu, Li-li</au><au>Liu, Hong-ning</au><au>Zhu, Wei-feng</au><au>Yi, Wen-jiao</au><au>Zhao, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study</atitle><jtitle>Yao hsüeh hsüeh pao</jtitle><addtitle>Yao Xue Xue Bao</addtitle><date>2010-07</date><risdate>2010</risdate><volume>45</volume><issue>7</issue><spage>891</spage><epage>894</epage><pages>891-894</pages><issn>0513-4870</issn><abstract>To establish an LC-MS/MS method for simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of Fritillaria thunbergii Miq. extract, the pharmacokinetic parameters were calculated as well. Peimine, peiminine and internal standard carbamazepine were extracted from plasma with liquid-liquid extraction by ethyl acetate, then separated on a Luna C18 column by using acetonitrile-water containing 10 mmol x L(-1) ammonium formate (35:65), as mobile phase. The electrospray ionization (ESI) source was applied and operated in positive ion mode. Peimine was detected at m/z 432.4 --> 414.4, peiminine at m/z 430.4 --> 412.4 and carbamazepine (IS) at 237.1 --> 194.2. The linear calibration curves were obtained at the concentration range of 0.8-800 ng x mL(-1) for peimine and peiminine. The extraction recoveries were 94.1%-105.3% and 85.8%-98.6%, respectively. The precisions, accuracy and stability of the analytes meet the requirements. The method was shown to be effective,</abstract><cop>China</cop><pmid>20931788</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Yao hsüeh hsüeh pao, 2010-07, Vol.45 (7), p.891-894 |
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| language | chi |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Cevanes - blood Cevanes - pharmacokinetics Chromatography, Liquid - methods Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacokinetics Female Fritillaria - chemistry Injections, Intravenous Plants, Medicinal - chemistry Rats Rats, Sprague-Dawley Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods |
| title | Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study |
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