Glucocorticoid metabolism and reproduction: a tale of two enzymes
Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-d...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2003-10, Vol.126 (4), p.425-441 |
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| creator | Michael, AE Thurston, LM Rae, MT |
| description | Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids. Whereas the regeneration of active glucocorticoids by 11 beta HSD1 has been implicated in the cellular mechanisms of pituitary function, ovulation and parturition, the enzymatic inactivation of cortisol and corticosterone by 11 beta HSD enzymes appears to be central to the protection of gonadal steroidogenesis, prevention of intra-uterine growth retardation, and lactation. Recent evidence indicates that follicular fluid contains endogenous modulators of cortisol metabolism by 11 beta HSD1, the concentrations of which are associated with the clinical outcome of assisted conception cycles and are altered in cystic ovarian disease. In conclusion, the two cloned isoforms of 11 beta HSD fulfil diverse roles in a wide range of reproductive processes from conception to lactation. |
| doi_str_mv | 10.1530/rep.0.1260425 |
| format | Article |
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To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids. Whereas the regeneration of active glucocorticoids by 11 beta HSD1 has been implicated in the cellular mechanisms of pituitary function, ovulation and parturition, the enzymatic inactivation of cortisol and corticosterone by 11 beta HSD enzymes appears to be central to the protection of gonadal steroidogenesis, prevention of intra-uterine growth retardation, and lactation. Recent evidence indicates that follicular fluid contains endogenous modulators of cortisol metabolism by 11 beta HSD1, the concentrations of which are associated with the clinical outcome of assisted conception cycles and are altered in cystic ovarian disease. In conclusion, the two cloned isoforms of 11 beta HSD fulfil diverse roles in a wide range of reproductive processes from conception to lactation.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/rep.0.1260425</identifier><identifier>PMID: 14525525</identifier><language>eng</language><publisher>Colchester: Society for Reproduction and Fertility</publisher><subject>11-beta-Hydroxysteroid Dehydrogenases - metabolism ; Animals ; Biological and medical sciences ; Corticosterone - metabolism ; Embryonic and Fetal Development ; Female ; Fertilization in Vitro ; Fetal Growth Retardation - enzymology ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - metabolism ; Humans ; Hydrocortisone - metabolism ; Hypothalamus - enzymology ; Isoenzymes - metabolism ; Labor, Obstetric ; Lipids. Glycolipids ; Male ; Mammary Glands, Animal - enzymology ; Metabolisms and neurohumoral controls ; Ovary - enzymology ; Pituitary Gland, Anterior - enzymology ; Pregnancy ; Reproduction - physiology ; Spermatozoa - enzymology ; Testis - enzymology ; Uterus - enzymology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: reproduction</subject><ispartof>Reproduction (Cambridge, England), 2003-10, Vol.126 (4), p.425-441</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b545t-cce367ae1f74f7acace644d3cec10129736ccbe64e0b038d286ddd597fe4ee813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15215095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14525525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michael, AE</creatorcontrib><creatorcontrib>Thurston, LM</creatorcontrib><creatorcontrib>Rae, MT</creatorcontrib><title>Glucocorticoid metabolism and reproduction: a tale of two enzymes</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids. Whereas the regeneration of active glucocorticoids by 11 beta HSD1 has been implicated in the cellular mechanisms of pituitary function, ovulation and parturition, the enzymatic inactivation of cortisol and corticosterone by 11 beta HSD enzymes appears to be central to the protection of gonadal steroidogenesis, prevention of intra-uterine growth retardation, and lactation. Recent evidence indicates that follicular fluid contains endogenous modulators of cortisol metabolism by 11 beta HSD1, the concentrations of which are associated with the clinical outcome of assisted conception cycles and are altered in cystic ovarian disease. In conclusion, the two cloned isoforms of 11 beta HSD fulfil diverse roles in a wide range of reproductive processes from conception to lactation.</description><subject>11-beta-Hydroxysteroid Dehydrogenases - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Corticosterone - metabolism</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Fetal Growth Retardation - enzymology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - metabolism</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypothalamus - enzymology</subject><subject>Isoenzymes - metabolism</subject><subject>Labor, Obstetric</subject><subject>Lipids. Glycolipids</subject><subject>Male</subject><subject>Mammary Glands, Animal - enzymology</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Ovary - enzymology</subject><subject>Pituitary Gland, Anterior - enzymology</subject><subject>Pregnancy</subject><subject>Reproduction - physiology</subject><subject>Spermatozoa - enzymology</subject><subject>Testis - enzymology</subject><subject>Uterus - enzymology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: reproduction</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLxDAQhYMouq4evUoveuuatEnTepNFV2HBi55LOpm6kbbRpEXWX2-WFhYEhUAew5c3L4-QC0YXTKT0xuHHIsgkozwRB2TGJGexzIviMGguacyyJDshp96_U8pELrNjcsK4SEQ4M3K3agawYF1vwBodtdiryjbGt5HqdBTcndUD9MZ2t5GKetVgZOuo_7IRdt_bFv0ZOapV4_F8uufk9eH-ZfkYr59XT8u7dVwJLvoYANNMKmS15LVUoAAzznUKCIyypJBpBlCFGdKKprlO8kxrLQpZI0fMWTon16NvSPQ5oO_L1njAplEd2sGXUkjO87wIYDyC4Kz3Duvyw5lWuW3JaLnrrAy_KoMcOwv85WQ8VC3qPT2VFICrCVAeVFM71YHxe04kTNBix_GR25i3zZdxWFbGejDY9aY2oP7cn47PftH_p_4B3mWXzg</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Michael, AE</creator><creator>Thurston, LM</creator><creator>Rae, MT</creator><general>Society for Reproduction and Fertility</general><general>Portland</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Glucocorticoid metabolism and reproduction: a tale of two enzymes</title><author>Michael, AE ; Thurston, LM ; Rae, MT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b545t-cce367ae1f74f7acace644d3cec10129736ccbe64e0b038d286ddd597fe4ee813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>11-beta-Hydroxysteroid Dehydrogenases - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Corticosterone - metabolism</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Fetal Growth Retardation - enzymology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - metabolism</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypothalamus - enzymology</topic><topic>Isoenzymes - metabolism</topic><topic>Labor, Obstetric</topic><topic>Lipids. Glycolipids</topic><topic>Male</topic><topic>Mammary Glands, Animal - enzymology</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Ovary - enzymology</topic><topic>Pituitary Gland, Anterior - enzymology</topic><topic>Pregnancy</topic><topic>Reproduction - physiology</topic><topic>Spermatozoa - enzymology</topic><topic>Testis - enzymology</topic><topic>Uterus - enzymology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michael, AE</creatorcontrib><creatorcontrib>Thurston, LM</creatorcontrib><creatorcontrib>Rae, MT</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michael, AE</au><au>Thurston, LM</au><au>Rae, MT</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoid metabolism and reproduction: a tale of two enzymes</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>126</volume><issue>4</issue><spage>425</spage><epage>441</epage><pages>425-441</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids. Whereas the regeneration of active glucocorticoids by 11 beta HSD1 has been implicated in the cellular mechanisms of pituitary function, ovulation and parturition, the enzymatic inactivation of cortisol and corticosterone by 11 beta HSD enzymes appears to be central to the protection of gonadal steroidogenesis, prevention of intra-uterine growth retardation, and lactation. Recent evidence indicates that follicular fluid contains endogenous modulators of cortisol metabolism by 11 beta HSD1, the concentrations of which are associated with the clinical outcome of assisted conception cycles and are altered in cystic ovarian disease. In conclusion, the two cloned isoforms of 11 beta HSD fulfil diverse roles in a wide range of reproductive processes from conception to lactation.</abstract><cop>Colchester</cop><pub>Society for Reproduction and Fertility</pub><pmid>14525525</pmid><doi>10.1530/rep.0.1260425</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 11-beta-Hydroxysteroid Dehydrogenases - metabolism Animals Biological and medical sciences Corticosterone - metabolism Embryonic and Fetal Development Female Fertilization in Vitro Fetal Growth Retardation - enzymology Fundamental and applied biological sciences. Psychology Glucocorticoids - metabolism Humans Hydrocortisone - metabolism Hypothalamus - enzymology Isoenzymes - metabolism Labor, Obstetric Lipids. Glycolipids Male Mammary Glands, Animal - enzymology Metabolisms and neurohumoral controls Ovary - enzymology Pituitary Gland, Anterior - enzymology Pregnancy Reproduction - physiology Spermatozoa - enzymology Testis - enzymology Uterus - enzymology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: reproduction |
| title | Glucocorticoid metabolism and reproduction: a tale of two enzymes |
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