Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation
Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemis...
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Veröffentlicht in: | FEBS letters 2003-09, Vol.552 (2), p.141-144 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria. |
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ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/S0014-5793(03)00905-0 |