The diversity of globin-coupled sensors

The recently discovered globin-coupled sensors (GCSs) are heme-containing two-domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi-domain C-terminal transmitters through a search of the complete and incomplete microbial genome datas...

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Veröffentlicht in:FEBS Letters 2003-09, Vol.552 (2), p.99-104
Hauptverfasser: Freitas, Tracey Allen K, Hou, Shaobin, Alam, Maqsudul
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container_title FEBS Letters
container_volume 552
creator Freitas, Tracey Allen K
Hou, Shaobin
Alam, Maqsudul
description The recently discovered globin-coupled sensors (GCSs) are heme-containing two-domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi-domain C-terminal transmitters through a search of the complete and incomplete microbial genome datasets. The GCS superfamily is composed of two major subfamilies: the aerotactic and gene regulators. We postulate the existence of protoglobin in Archaea as the predecessor to the chimeric GCS.
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subjects Amino Acid Sequence
Archaeal Proteins - chemistry
Archaeal Proteins - genetics
Archaeal Proteins - metabolism
Archaeon
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Globin
Globin-coupled sensor
Globins - chemistry
Globins - genetics
Globins - metabolism
Heme-based sensor
Hemeproteins - chemistry
Hemeproteins - genetics
Hemeproteins - metabolism
Molecular Sequence Data
Phylogeny
Protein Structure, Secondary
Sequence Homology, Amino Acid
title The diversity of globin-coupled sensors
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