Comparative conformational analysis and in vitro pharmacological evaluation of three cyclic hexapeptide NK-2 antagonists

The conformational analysis of three cyclic hexapeptides is presented. Cyclo‐(‐Gln6‐Trp7‐Phe8‐Gly9‐Leu10‐d‐Met11‐) (1) and cyclo‐(‐Gln6‐Trp7‐Phe8‐Gly9‐Leu10‐Met11‐) (2) are NK‐2 antagonists in the hamster trachea assay, whereas cyclo‐(‐Gln6‐Trp7‐Phe8‐(R)‐Gly9‐[ANC‐2]Leu10‐Met11‐) (3), where Gly9[ANC...

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Veröffentlicht in:	International Journal of Peptide and Protein Research 1993-04, Vol.41 (4), p.376-384
Hauptverfasser:	WOLLBORN, U., BRUNNE, R.M., HARTING, J., HÖLZEMANN, G., LEIBFRITZ, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Computer Simulation conformational analysis Cricetinae Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy - methods Models, Chemical Molecular biophysics Molecular Conformation molecular dynamics Molecular Sequence Data NK-2 antagonists nuclear magnetic resonance Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Tachykinin Structure in molecular biology Structure-Activity Relationship Tachykinins - antagonists & inhibitors Thermodynamics Trachea - drug effects Tridimensional structure
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