Translational control of ornithine-δ-aminotransferase (OAT) by estrogen

Ornithine-δ-aminotransferase (OAT) catalyzes the reversible transamination of ornithine to glutamate semialdehyde. OAT is abundant in liver, kidney and retina; hereditary deficiency of the enzyme leads to chorioretinal degeneration. Studies of OAT regulation in retinoblastomas have revealed an alter...

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Veröffentlicht in:	Molecular and cellular endocrinology 1993, Vol.90 (2), p.171-177
Hauptverfasser:	Fagan, Richard J., Rozen, Rima
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Analytical, structural and metabolic biochemistry Biological and medical sciences Cycloheximide - pharmacology Enzymes and enzyme inhibitors Estradiol - pharmacology Estrogen Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Humans Ornithine aminotransferase Ornithine-Oxo-Acid Transaminase - biosynthesis Ornithine-Oxo-Acid Transaminase - genetics Polymerase Chain Reaction Polyribosomes - metabolism Protein Biosynthesis - drug effects Retinoblastoma - metabolism RNA, Messenger - biosynthesis Transcription, Genetic - drug effects Transferases Translation Triiodothyronine - pharmacology Tumor Cells, Cultured
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