Nitric oxide synthase induction in glial cells: Effect on neuronal survival

In primary rat cortical glial cell cultures lipopolysaccharide (LPS) induced a dose- and time-dependent increase of intracellular cyclic GMP concentration associated with a release of nitrite. The LPS-induced cyclic GMP and nitrite increase was enhanced by interferon-γ and was prevented by L-N G- ni...

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Veröffentlicht in:	Life sciences (1973) 1993, Vol.52 (23), p.1883-1890
Hauptverfasser:	Demerlé-Pallardy, Caroline, Lonchampt, Marie-Odile, Chabrier, Pierre-Etienne, Braquet, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - biosynthesis Animals Biological and medical sciences Brain - cytology Brain - enzymology Cell Survival - physiology Cells, Cultured Cyclic GMP - metabolism Dose-Response Relationship, Drug Enzyme Induction Fundamental and applied biological sciences. Psychology Interferon-gamma - pharmacology Isolated neuron and nerve. Neuroglia Lipopolysaccharides - pharmacology Neuroglia - cytology Neuroglia - enzymology Nitric Oxide Synthase Nitrites - metabolism Rats Rats, Wistar Recombinant Proteins Vertebrates: nervous system and sense organs
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