Lp(a) LIPOPROTEIN AND HLA-DR GENOTYPE IN EARLY CORONARY ARTERY DISEASE
SUMMARY The interest in Lp(a) lipoprotein [Lp(a)] has increased dramatically during the last few years due to the documented strong association between high Lp(a) levels and early atherosclerosis and its sequelae and the probable additional thrombogenic effect of inherited high Lp(a) levels. However...
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| Veröffentlicht in: | European journal of immunogenetics 1993-04, Vol.20 (2), p.95-102 |
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| container_title | European journal of immunogenetics |
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| creator | Dahlén, G.H. Slunga, L. Holmlund, G. Langö, A. Lindblom, B. |
| description | SUMMARY
The interest in Lp(a) lipoprotein [Lp(a)] has increased dramatically during the last few years due to the documented strong association between high Lp(a) levels and early atherosclerosis and its sequelae and the probable additional thrombogenic effect of inherited high Lp(a) levels.
However, some paradoxes still remain to be solved in Lp(a) research. This pilot study was performed to test whether some criteria could be found for an association between Lp(a) levels, HLA genotype, and early coronary heart disease. If so, it could help to explain why some individuals with high Lp(a) levels get atherosclerosis while others with comparable lipid levels do not. It would also indicate that immunological processes could be involved in Lp(a) associated atherosclerosis.
In this case‐control study the HLA‐DR genotypes 13 or 17 were significantly more frequently encountered in 30 male patients with early coronary heart disease than in 30 sex and age matched healthy controls (P = 0.012). These HLA‐DR specificities were especially frequent in male patients with high Lp(a) levels. The same HLA‐DR genotype pattern was not seen in 30 female patients, although there was a trend towards more frequent 13a genotype. |
| doi_str_mv | 10.1111/j.1744-313X.1993.tb00098.x |
| format | Article |
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The interest in Lp(a) lipoprotein [Lp(a)] has increased dramatically during the last few years due to the documented strong association between high Lp(a) levels and early atherosclerosis and its sequelae and the probable additional thrombogenic effect of inherited high Lp(a) levels.
However, some paradoxes still remain to be solved in Lp(a) research. This pilot study was performed to test whether some criteria could be found for an association between Lp(a) levels, HLA genotype, and early coronary heart disease. If so, it could help to explain why some individuals with high Lp(a) levels get atherosclerosis while others with comparable lipid levels do not. It would also indicate that immunological processes could be involved in Lp(a) associated atherosclerosis.
In this case‐control study the HLA‐DR genotypes 13 or 17 were significantly more frequently encountered in 30 male patients with early coronary heart disease than in 30 sex and age matched healthy controls (P = 0.012). These HLA‐DR specificities were especially frequent in male patients with high Lp(a) levels. The same HLA‐DR genotype pattern was not seen in 30 female patients, although there was a trend towards more frequent 13a genotype.</description><identifier>ISSN: 1744-3121</identifier><identifier>ISSN: 0960-7420</identifier><identifier>EISSN: 1744-313X</identifier><identifier>EISSN: 1365-2370</identifier><identifier>DOI: 10.1111/j.1744-313X.1993.tb00098.x</identifier><identifier>PMID: 8494873</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Coronary Disease - blood ; Coronary Disease - genetics ; Coronary Disease - immunology ; Female ; Gene Frequency ; Genotype ; HLA-DR Antigens - genetics ; Humans ; Lipoprotein(a) - blood ; Male ; Medical sciences ; Middle Aged ; Risk Factors ; Sex Characteristics</subject><ispartof>European journal of immunogenetics, 1993-04, Vol.20 (2), p.95-102</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4665-af1868c97cb33aeed739acf72f2d3a6293f054cc22a98e232c12e26e4df535cc3</citedby><cites>FETCH-LOGICAL-c4665-af1868c97cb33aeed739acf72f2d3a6293f054cc22a98e232c12e26e4df535cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1744-313X.1993.tb00098.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1744-313X.1993.tb00098.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4926391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8494873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dahlén, G.H.</creatorcontrib><creatorcontrib>Slunga, L.</creatorcontrib><creatorcontrib>Holmlund, G.</creatorcontrib><creatorcontrib>Langö, A.</creatorcontrib><creatorcontrib>Lindblom, B.</creatorcontrib><title>Lp(a) LIPOPROTEIN AND HLA-DR GENOTYPE IN EARLY CORONARY ARTERY DISEASE</title><title>European journal of immunogenetics</title><addtitle>Eur J Immunogenet</addtitle><description>SUMMARY
The interest in Lp(a) lipoprotein [Lp(a)] has increased dramatically during the last few years due to the documented strong association between high Lp(a) levels and early atherosclerosis and its sequelae and the probable additional thrombogenic effect of inherited high Lp(a) levels.
However, some paradoxes still remain to be solved in Lp(a) research. This pilot study was performed to test whether some criteria could be found for an association between Lp(a) levels, HLA genotype, and early coronary heart disease. If so, it could help to explain why some individuals with high Lp(a) levels get atherosclerosis while others with comparable lipid levels do not. It would also indicate that immunological processes could be involved in Lp(a) associated atherosclerosis.
In this case‐control study the HLA‐DR genotypes 13 or 17 were significantly more frequently encountered in 30 male patients with early coronary heart disease than in 30 sex and age matched healthy controls (P = 0.012). These HLA‐DR specificities were especially frequent in male patients with high Lp(a) levels. The same HLA‐DR genotype pattern was not seen in 30 female patients, although there was a trend towards more frequent 13a genotype.</description><subject>Adult</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - genetics</subject><subject>Coronary Disease - immunology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sex Characteristics</subject><issn>1744-3121</issn><issn>0960-7420</issn><issn>1744-313X</issn><issn>1365-2370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhsVY6df2EwpmjLFd2NOXJauwC5O4qYtnByejzZVQFBmcOk1mJTT995OJ8e2obo447_tK5zwAfEEwQO78XAeIU-oTRJ4CJAQJ9ksIoYiC4wdwOUgfhztGF-DK2jWEhFEKz8F5RAWNOLkEd9nuu_rhZem0mJbFPElzL87H3n0W--PSmyR5MV9ME8-1k7jMFt6oKIs8LhdeXM4TV8bpLIlnySdwVqnGms99vQZ_7pL56N7Pikk6ijNfU8ZCX1UoYpEWXC8JUcasOBFKVxxXeEUUw4JUMKRaY6xEZDDBGmGDmaGrKiSh1uQafDu9u2u3fw_G7uWmtto0jXox24OVPOQUYYfkf0bE3P4wQs54ezLqdmttayq5a-uNat8kgrKjLdeywyg7pLKjLXva8ujCN_0vh-XGrIZoj9fpX3tdWa2aqlUvuraDjQrMiOhm-HWyvdaNeXvHADJ9SEXo8v4pX9u9OQ551T5LxgkP5WM-kbNHCJ_GD79lRv4BvU2kVA</recordid><startdate>199304</startdate><enddate>199304</enddate><creator>Dahlén, G.H.</creator><creator>Slunga, L.</creator><creator>Holmlund, G.</creator><creator>Langö, A.</creator><creator>Lindblom, B.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199304</creationdate><title>Lp(a) LIPOPROTEIN AND HLA-DR GENOTYPE IN EARLY CORONARY ARTERY DISEASE</title><author>Dahlén, G.H. ; Slunga, L. ; Holmlund, G. ; Langö, A. ; Lindblom, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4665-af1868c97cb33aeed739acf72f2d3a6293f054cc22a98e232c12e26e4df535cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - genetics</topic><topic>Coronary Disease - immunology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>HLA-DR Antigens - genetics</topic><topic>Humans</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dahlén, G.H.</creatorcontrib><creatorcontrib>Slunga, L.</creatorcontrib><creatorcontrib>Holmlund, G.</creatorcontrib><creatorcontrib>Langö, A.</creatorcontrib><creatorcontrib>Lindblom, B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dahlén, G.H.</au><au>Slunga, L.</au><au>Holmlund, G.</au><au>Langö, A.</au><au>Lindblom, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lp(a) LIPOPROTEIN AND HLA-DR GENOTYPE IN EARLY CORONARY ARTERY DISEASE</atitle><jtitle>European journal of immunogenetics</jtitle><addtitle>Eur J Immunogenet</addtitle><date>1993-04</date><risdate>1993</risdate><volume>20</volume><issue>2</issue><spage>95</spage><epage>102</epage><pages>95-102</pages><issn>1744-3121</issn><issn>0960-7420</issn><eissn>1744-313X</eissn><eissn>1365-2370</eissn><abstract>SUMMARY
The interest in Lp(a) lipoprotein [Lp(a)] has increased dramatically during the last few years due to the documented strong association between high Lp(a) levels and early atherosclerosis and its sequelae and the probable additional thrombogenic effect of inherited high Lp(a) levels.
However, some paradoxes still remain to be solved in Lp(a) research. This pilot study was performed to test whether some criteria could be found for an association between Lp(a) levels, HLA genotype, and early coronary heart disease. If so, it could help to explain why some individuals with high Lp(a) levels get atherosclerosis while others with comparable lipid levels do not. It would also indicate that immunological processes could be involved in Lp(a) associated atherosclerosis.
In this case‐control study the HLA‐DR genotypes 13 or 17 were significantly more frequently encountered in 30 male patients with early coronary heart disease than in 30 sex and age matched healthy controls (P = 0.012). These HLA‐DR specificities were especially frequent in male patients with high Lp(a) levels. The same HLA‐DR genotype pattern was not seen in 30 female patients, although there was a trend towards more frequent 13a genotype.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8494873</pmid><doi>10.1111/j.1744-313X.1993.tb00098.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of immunogenetics, 1993-04, Vol.20 (2), p.95-102 |
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| subjects | Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary Disease - blood Coronary Disease - genetics Coronary Disease - immunology Female Gene Frequency Genotype HLA-DR Antigens - genetics Humans Lipoprotein(a) - blood Male Medical sciences Middle Aged Risk Factors Sex Characteristics |
| title | Lp(a) LIPOPROTEIN AND HLA-DR GENOTYPE IN EARLY CORONARY ARTERY DISEASE |
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