Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase

Background & Aims : Growth hormone (GH) has been shown to alleviate symptoms in patients with Crohn’s disease. Chloride secretion is important in driving intestinal fluid secretion. We examined whether GH inhibits chloride secretion induced by carbachol (CCh, a calcium-dependent pathway), and th...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2003-10, Vol.125 (4), p.1114-1124
Hauptverfasser:	Chow, Jimmy Y.C, Carlstrom, Katie, Barrett, Kim E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Transport - drug effects Carbachol - pharmacology Cell Line Chlorides - metabolism Cholinergic Agonists - pharmacology Enzyme Inhibitors - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism ErbB Receptors - metabolism Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Human Growth Hormone - pharmacology Humans Imidazoles - pharmacology Intestinal Mucosa - cytology Intestine. Mesentery Janus Kinase 2 MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Pyridines - pharmacology Tyrosine - metabolism Vertebrates: digestive system
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