Behavioral studies of emetic sensitivity in the ferret
The ferrets' responsiveness to several known and putative emetic agents was evaluated using a variety of agents that were injected subcutaneously and/or intravenously. Apomorphine was consistently emetic at relatively high doses (100 μg/kg) when injected subcutaneously in large male ferrets (≥1...
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| Veröffentlicht in: | Brain research bulletin 1993, Vol.31 (5), p.477-484 |
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| creator | Knox, A.P. Strominger, N.L. Battles, A.H. Carpenter, D.O. |
| description | The ferrets' responsiveness to several known and putative emetic agents was evaluated using a variety of agents that were injected subcutaneously and/or intravenously. Apomorphine was consistently emetic at relatively high doses (100 μg/kg) when injected subcutaneously in large male ferrets (≥1.4 kg). The responsiveness to apomorphine was anomalous in that subcutaneous injections produced a more consistent response than intravenous ones. In addition, ferrets rapidly become tolerant or tachyphylactic to subcutaneously administered apomorphine. Area postrema ablation, but not abdominal vagotomy, rendered ferrets refractory to the emetic effects of apomorphine. This species, relative to dog and humans, proved to be insensitive to a variety of pharmacologic agents including angiotensin II, gastrin, histamine, Leu-enkephalin, neurotensin, serotonin, and vasopressin. Cisplatin elicited forceful retching and emesis. Emetic responses were obtained with substance P and Met-enkephalin in individual animals but were inconsistent. Sensitivity to DAGO [D-Ala
2, MePhe
4,Gly-ol
5 enkephalin] was variable. Results of this study indicate that the ferret is not an optimal model for all forms of emesis. |
| doi_str_mv | 10.1016/0361-9230(93)90112-O |
| format | Article |
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2, MePhe
4,Gly-ol
5 enkephalin] was variable. Results of this study indicate that the ferret is not an optimal model for all forms of emesis.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(93)90112-O</identifier><identifier>PMID: 8495372</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Apomorphine - administration & dosage ; Apomorphine - pharmacology ; Behavior ; Behavior, Animal - drug effects ; Biological and medical sciences ; Emesis ; Emetic sensitivity ; Emetics - administration & dosage ; Emetics - pharmacology ; Female ; Ferrets ; Fundamental and applied biological sciences. Psychology ; Injections, Intravenous ; Injections, Subcutaneous ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Species Specificity ; Tachyphylaxis - physiology ; Tegmentum Mesencephali - anatomy & histology ; Tegmentum Mesencephali - physiology ; Vagotomy ; Vertebrates: nervous system and sense organs ; Vomiting Apomorphine</subject><ispartof>Brain research bulletin, 1993, Vol.31 (5), p.477-484</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-f586229b0defdd0f5cfa4a74fd8245ee508de1c8d24407164bfd72ac32c29d253</citedby><cites>FETCH-LOGICAL-c534t-f586229b0defdd0f5cfa4a74fd8245ee508de1c8d24407164bfd72ac32c29d253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/036192309390112O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4709436$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8495372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knox, A.P.</creatorcontrib><creatorcontrib>Strominger, N.L.</creatorcontrib><creatorcontrib>Battles, A.H.</creatorcontrib><creatorcontrib>Carpenter, D.O.</creatorcontrib><title>Behavioral studies of emetic sensitivity in the ferret</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The ferrets' responsiveness to several known and putative emetic agents was evaluated using a variety of agents that were injected subcutaneously and/or intravenously. Apomorphine was consistently emetic at relatively high doses (100 μg/kg) when injected subcutaneously in large male ferrets (≥1.4 kg). The responsiveness to apomorphine was anomalous in that subcutaneous injections produced a more consistent response than intravenous ones. In addition, ferrets rapidly become tolerant or tachyphylactic to subcutaneously administered apomorphine. Area postrema ablation, but not abdominal vagotomy, rendered ferrets refractory to the emetic effects of apomorphine. This species, relative to dog and humans, proved to be insensitive to a variety of pharmacologic agents including angiotensin II, gastrin, histamine, Leu-enkephalin, neurotensin, serotonin, and vasopressin. Cisplatin elicited forceful retching and emesis. Emetic responses were obtained with substance P and Met-enkephalin in individual animals but were inconsistent. Sensitivity to DAGO [D-Ala
2, MePhe
4,Gly-ol
5 enkephalin] was variable. Results of this study indicate that the ferret is not an optimal model for all forms of emesis.</description><subject>Animals</subject><subject>Apomorphine - administration & dosage</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Emesis</subject><subject>Emetic sensitivity</subject><subject>Emetics - administration & dosage</subject><subject>Emetics - pharmacology</subject><subject>Female</subject><subject>Ferrets</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intravenous</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Species Specificity</subject><subject>Tachyphylaxis - physiology</subject><subject>Tegmentum Mesencephali - anatomy & histology</subject><subject>Tegmentum Mesencephali - physiology</subject><subject>Vagotomy</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vomiting Apomorphine</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMoWh__QGEWIroYzTuTjaDFFxS60XVIkxuMTGc0SQv-e6e2dKmruzjfOVw-hE4JviaYyBvMJKk1ZfhSsyuNCaH1dAeNSKNYTRVXu2i0RQ7QYc4fGGPZCLmP9huuBVN0hOQ9vNtl7JNtq1wWPkKu-lDBHEp0VYYuxxKXsXxXsavKO1QBUoJyjPaCbTOcbO4Rent8eB0_15Pp08v4blI7wXipg2gkpXqGPQTvcRAuWG4VD76hXAAI3HggrvGUc6yI5LPgFbWOUUe1p4IdoYv17mfqvxaQi5nH7KBtbQf9IhslFFOa6H9BIgXlDWEDyNegS33OCYL5THFu07ch2Ky8mpU0s5JmNDO_Xs10qJ1t9hezOfhtaSNyyM83uc3OtiHZzsW8xbjCmjM5YLdrDAZpywjJZBehc-BjAleM7-Pff_wAxYOTRA</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Knox, A.P.</creator><creator>Strominger, N.L.</creator><creator>Battles, A.H.</creator><creator>Carpenter, D.O.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Behavioral studies of emetic sensitivity in the ferret</title><author>Knox, A.P. ; Strominger, N.L. ; Battles, A.H. ; Carpenter, D.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-f586229b0defdd0f5cfa4a74fd8245ee508de1c8d24407164bfd72ac32c29d253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Apomorphine - administration & dosage</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Emesis</topic><topic>Emetic sensitivity</topic><topic>Emetics - administration & dosage</topic><topic>Emetics - pharmacology</topic><topic>Female</topic><topic>Ferrets</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intravenous</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Species Specificity</topic><topic>Tachyphylaxis - physiology</topic><topic>Tegmentum Mesencephali - anatomy & histology</topic><topic>Tegmentum Mesencephali - physiology</topic><topic>Vagotomy</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vomiting Apomorphine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knox, A.P.</creatorcontrib><creatorcontrib>Strominger, N.L.</creatorcontrib><creatorcontrib>Battles, A.H.</creatorcontrib><creatorcontrib>Carpenter, D.O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knox, A.P.</au><au>Strominger, N.L.</au><au>Battles, A.H.</au><au>Carpenter, D.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral studies of emetic sensitivity in the ferret</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1993</date><risdate>1993</risdate><volume>31</volume><issue>5</issue><spage>477</spage><epage>484</epage><pages>477-484</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The ferrets' responsiveness to several known and putative emetic agents was evaluated using a variety of agents that were injected subcutaneously and/or intravenously. Apomorphine was consistently emetic at relatively high doses (100 μg/kg) when injected subcutaneously in large male ferrets (≥1.4 kg). The responsiveness to apomorphine was anomalous in that subcutaneous injections produced a more consistent response than intravenous ones. In addition, ferrets rapidly become tolerant or tachyphylactic to subcutaneously administered apomorphine. Area postrema ablation, but not abdominal vagotomy, rendered ferrets refractory to the emetic effects of apomorphine. This species, relative to dog and humans, proved to be insensitive to a variety of pharmacologic agents including angiotensin II, gastrin, histamine, Leu-enkephalin, neurotensin, serotonin, and vasopressin. Cisplatin elicited forceful retching and emesis. Emetic responses were obtained with substance P and Met-enkephalin in individual animals but were inconsistent. Sensitivity to DAGO [D-Ala
2, MePhe
4,Gly-ol
5 enkephalin] was variable. Results of this study indicate that the ferret is not an optimal model for all forms of emesis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8495372</pmid><doi>10.1016/0361-9230(93)90112-O</doi><tpages>8</tpages></addata></record> |
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| ispartof | Brain research bulletin, 1993, Vol.31 (5), p.477-484 |
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| subjects | Animals Apomorphine - administration & dosage Apomorphine - pharmacology Behavior Behavior, Animal - drug effects Biological and medical sciences Emesis Emetic sensitivity Emetics - administration & dosage Emetics - pharmacology Female Ferrets Fundamental and applied biological sciences. Psychology Injections, Intravenous Injections, Subcutaneous Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Species Specificity Tachyphylaxis - physiology Tegmentum Mesencephali - anatomy & histology Tegmentum Mesencephali - physiology Vagotomy Vertebrates: nervous system and sense organs Vomiting Apomorphine |
| title | Behavioral studies of emetic sensitivity in the ferret |
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