The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids, and apolipoproteins
This study examined the relationship between the fatty acid composition of red blood cell phospholipids and lipid markers of atherosclerotic risk in an urban male population aged 45 to 66 years. There was a surprisingly significant positive association between the docosahexaenoic acid ([DHA] 22:6n-3...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1993-05, Vol.42 (5), p.562-568 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Theret, N. Bard, J.M. Nuttens, M.C. Lecerf, J.M. Delbart, C. Romon, M. Salomez, J.L. Fruchart, J.C. |
| description | This study examined the relationship between the fatty acid composition of red blood cell phospholipids and lipid markers of atherosclerotic risk in an urban male population aged 45 to 66 years. There was a surprisingly significant positive association between the docosahexaenoic acid ([DHA] 22:6n-3) content of erythrocyte phospholipids and the following risk markers: plasma cholesterol (
P < .01), low-density lipoprotein (LDL) cholesterol (
P < .01), apolipoprotein (apo) B (
P < .05), and apo B-containing lipoprotein particles (
P < .05) recognized by a monoclonal antibody (LpBL3). On the other hand, phospholipid α-linolenate was positively correlated with apo A-I and high-density lipoprotein (HDL) cholesterol levels (
P < .05), while arachidonate showed an inverse relationship with plasma cholesterol level (
P < .05). There was a negative association between palmitoleic acid and apo B (
P < .01) and LpBL3 (
P < .001); the latter showed a negative association with stearic acid (
P < .001). These interesting findings emphasize the beneficial effect on atherosclerotic risk markers of dietary n-6 polyunsaturated and monounsaturated fatty acids, and suggest that long-chain n-3 polyunsaturated fatty acids (DHA) could have an adverse effect on some of the lipid risk markers. |
| doi_str_mv | 10.1016/0026-0495(93)90213-8 |
| format | Article |
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P < .01), low-density lipoprotein (LDL) cholesterol (
P < .01), apolipoprotein (apo) B (
P < .05), and apo B-containing lipoprotein particles (
P < .05) recognized by a monoclonal antibody (LpBL3). On the other hand, phospholipid α-linolenate was positively correlated with apo A-I and high-density lipoprotein (HDL) cholesterol levels (
P < .05), while arachidonate showed an inverse relationship with plasma cholesterol level (
P < .05). There was a negative association between palmitoleic acid and apo B (
P < .01) and LpBL3 (
P < .001); the latter showed a negative association with stearic acid (
P < .001). These interesting findings emphasize the beneficial effect on atherosclerotic risk markers of dietary n-6 polyunsaturated and monounsaturated fatty acids, and suggest that long-chain n-3 polyunsaturated fatty acids (DHA) could have an adverse effect on some of the lipid risk markers.]]></description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(93)90213-8</identifier><identifier>PMID: 8492710</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Apolipoproteins - blood ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary heart disease ; Erythrocytes - metabolism ; Fatty Acids - blood ; Heart ; Humans ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Phospholipids - blood ; Regression Analysis</subject><ispartof>Metabolism, clinical and experimental, 1993-05, Vol.42 (5), p.562-568</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-5982eee25665f1f690a9133b137e91958e2173284604fed0b3afaed6039a5ade3</citedby><cites>FETCH-LOGICAL-c452t-5982eee25665f1f690a9133b137e91958e2173284604fed0b3afaed6039a5ade3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(93)90213-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4847717$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8492710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theret, N.</creatorcontrib><creatorcontrib>Bard, J.M.</creatorcontrib><creatorcontrib>Nuttens, M.C.</creatorcontrib><creatorcontrib>Lecerf, J.M.</creatorcontrib><creatorcontrib>Delbart, C.</creatorcontrib><creatorcontrib>Romon, M.</creatorcontrib><creatorcontrib>Salomez, J.L.</creatorcontrib><creatorcontrib>Fruchart, J.C.</creatorcontrib><title>The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids, and apolipoproteins</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description><![CDATA[This study examined the relationship between the fatty acid composition of red blood cell phospholipids and lipid markers of atherosclerotic risk in an urban male population aged 45 to 66 years. There was a surprisingly significant positive association between the docosahexaenoic acid ([DHA] 22:6n-3) content of erythrocyte phospholipids and the following risk markers: plasma cholesterol (
P < .01), low-density lipoprotein (LDL) cholesterol (
P < .01), apolipoprotein (apo) B (
P < .05), and apo B-containing lipoprotein particles (
P < .05) recognized by a monoclonal antibody (LpBL3). On the other hand, phospholipid α-linolenate was positively correlated with apo A-I and high-density lipoprotein (HDL) cholesterol levels (
P < .05), while arachidonate showed an inverse relationship with plasma cholesterol level (
P < .05). There was a negative association between palmitoleic acid and apo B (
P < .01) and LpBL3 (
P < .001); the latter showed a negative association with stearic acid (
P < .001). These interesting findings emphasize the beneficial effect on atherosclerotic risk markers of dietary n-6 polyunsaturated and monounsaturated fatty acids, and suggest that long-chain n-3 polyunsaturated fatty acids (DHA) could have an adverse effect on some of the lipid risk markers.]]></description><subject>Apolipoproteins - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Erythrocytes - metabolism</subject><subject>Fatty Acids - blood</subject><subject>Heart</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phospholipids - blood</subject><subject>Regression Analysis</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuKFDEUhoMoY9v6BgpZiChYmkvlthFk8AYDbsZ1SCUndKSqUibVDvP2pqabXroISfgvOfkQeknJB0qo_EgIkx3pjXhr-DtDGOWdfoR2VHDWaUnIY7S7WJ6iZ7X-JoQopeUVutK9YYqSHbq7PQAuMLo15bke0oIHWO8AZrw2YTnk2taYlhRwdOt6j51vR5-nJde0ZXCOLR_wMObcBBjH-h4vo6uTww-5dnVzwG7ZavJS8gpprs_Rk-jGCi_O-x79-vrl9vp7d_Pz24_rzzed7wVbO2E0AwAmpBSRRmmIM5TzgXIFhhqhgVHFme4l6SMEMnAXHQRJuHHCBeB79ObU2x7-c4S62inVbUo3Qz5Wq4TiSmjRjP3J6EuutUC0S0mTK_eWErvxthtMu8G0htsH3la32Ktz_3GYIFxCZ8BNf33WXfVujMXNPtWLrde9Uu0He_TpZIPG4m-CYqtPMHsIqYBfbcjp_3P8A2fanVc</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Theret, N.</creator><creator>Bard, J.M.</creator><creator>Nuttens, M.C.</creator><creator>Lecerf, J.M.</creator><creator>Delbart, C.</creator><creator>Romon, M.</creator><creator>Salomez, J.L.</creator><creator>Fruchart, J.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids, and apolipoproteins</title><author>Theret, N. ; Bard, J.M. ; Nuttens, M.C. ; Lecerf, J.M. ; Delbart, C. ; Romon, M. ; Salomez, J.L. ; Fruchart, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-5982eee25665f1f690a9133b137e91958e2173284604fed0b3afaed6039a5ade3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Apolipoproteins - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Erythrocytes - metabolism</topic><topic>Fatty Acids - blood</topic><topic>Heart</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phospholipids - blood</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theret, N.</creatorcontrib><creatorcontrib>Bard, J.M.</creatorcontrib><creatorcontrib>Nuttens, M.C.</creatorcontrib><creatorcontrib>Lecerf, J.M.</creatorcontrib><creatorcontrib>Delbart, C.</creatorcontrib><creatorcontrib>Romon, M.</creatorcontrib><creatorcontrib>Salomez, J.L.</creatorcontrib><creatorcontrib>Fruchart, J.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theret, N.</au><au>Bard, J.M.</au><au>Nuttens, M.C.</au><au>Lecerf, J.M.</au><au>Delbart, C.</au><au>Romon, M.</au><au>Salomez, J.L.</au><au>Fruchart, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids, and apolipoproteins</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>42</volume><issue>5</issue><spage>562</spage><epage>568</epage><pages>562-568</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract><![CDATA[This study examined the relationship between the fatty acid composition of red blood cell phospholipids and lipid markers of atherosclerotic risk in an urban male population aged 45 to 66 years. There was a surprisingly significant positive association between the docosahexaenoic acid ([DHA] 22:6n-3) content of erythrocyte phospholipids and the following risk markers: plasma cholesterol (
P < .01), low-density lipoprotein (LDL) cholesterol (
P < .01), apolipoprotein (apo) B (
P < .05), and apo B-containing lipoprotein particles (
P < .05) recognized by a monoclonal antibody (LpBL3). On the other hand, phospholipid α-linolenate was positively correlated with apo A-I and high-density lipoprotein (HDL) cholesterol levels (
P < .05), while arachidonate showed an inverse relationship with plasma cholesterol level (
P < .05). There was a negative association between palmitoleic acid and apo B (
P < .01) and LpBL3 (
P < .001); the latter showed a negative association with stearic acid (
P < .001). These interesting findings emphasize the beneficial effect on atherosclerotic risk markers of dietary n-6 polyunsaturated and monounsaturated fatty acids, and suggest that long-chain n-3 polyunsaturated fatty acids (DHA) could have an adverse effect on some of the lipid risk markers.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8492710</pmid><doi>10.1016/0026-0495(93)90213-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1993-05, Vol.42 (5), p.562-568 |
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| subjects | Apolipoproteins - blood Biological and medical sciences Cardiology. Vascular system Coronary heart disease Erythrocytes - metabolism Fatty Acids - blood Heart Humans Lipids - blood Male Medical sciences Middle Aged Phospholipids - blood Regression Analysis |
| title | The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids, and apolipoproteins |
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