Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers. Microarray studies have shown that this phenotype is associated with breast cancers that express neither estrogen receptor (ER) nor erbB-2 (HER2/neu) (i.e., ER/erbB-2–negative tumors). The ER/erbB-2– negative...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2003-10, Vol.95 (19), p.1482-1485
Hauptverfasser:	Foulkes, William D., Stefansson, Ingunn M., Chappuis, Pierre O., Bégin, Louis R., Goffin, John R., Wong, Nora, Trudel, Michel, Akslen, Lars A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - genetics Carcinoma, Basal Cell - chemistry Carcinoma, Basal Cell - genetics Female Genes Genes, BRCA1 Germ-Line Mutation Gynecology. Andrology. Obstetrics Heterozygote Humans Keratins - analysis Mammary gland diseases Medical sciences Mutation Phenotype Tumors
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