Expression of the serotonin 1b receptor in experimental pulmonary hypertension

The pathogenesis of pulmonary arterial hypertension (PAH) remains uncertain. Both the serotonin and endothelin (ET) systems are believed to be involved. Recent studies pointed to the importance of the serotonin 2B receptor as a limiting step. The current authors investigated the lung tissue expressi...

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Veröffentlicht in:	The European respiratory journal 2003-09, Vol.22 (3), p.408-412
Hauptverfasser:	Rondelet, B, Van Beneden, R, Kerbaul, F, Motte, S, Fesler, P, McEntee, K, Brimioulle, S, Ketelslegers, J-M, Naeije, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - therapeutic use Bosentan Carrier Proteins - biosynthesis Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - metabolism Lung - metabolism Membrane Glycoproteins - biosynthesis Membrane Transport Proteins Nerve Tissue Proteins Polymerase Chain Reaction Pulmonary Circulation Receptor, Serotonin, 5-HT1B - biosynthesis Receptors, Endothelin - physiology Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins Sulfonamides - therapeutic use Swine
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