Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels
Signal transduction in vertebrate rod and cone photoreceptorcells involves ion channels that are directly gated by the internal messenger cGMP. Rods and each type of cones express genetically related yet different forms of photopigments. Enzymes that control the light-stimulated hydrolysis of cGMP i...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1993-05, Vol.10 (5), p.865-877 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 877 |
|---|---|
| container_issue | 5 |
| container_start_page | 865 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 10 |
| creator | Bönigk, Wolfgang Altenhofen, Wolfram Müller, Frank Dose, Andrea Illing, Michelle Molday, Robert S. Kaupp, U. Benjamin |
| description | Signal transduction in vertebrate rod and cone photoreceptorcells involves ion channels that are directly gated by the internal messenger cGMP. Rods and each type of cones express genetically related yet different forms of photopigments. Enzymes that control the light-stimulated hydrolysis of cGMP in rods and cones are also the product of distinct genes. Two different cDNA clones encoding cGMP-gated channels have been characterized from the chicken retina. Expression of cDNAs in Xenopus oocytes gives rise to cGMP-stimulated channel activity. Antibodies against a synthetic peptide specific for the C-terminal amino acid sequence derived from one clone stain outer segments of cone but not rod photoreceptors. Therefore chicken rod and cone cells each express different forms of cGMP-gated channels that are genetically related to each other. Expression in COS-1 cells produces the complete form of both channel polypeptides, whereas Western blot analysis indicates that channels in outer segment membranes are present in a processed form that is significantly shorter than the full-length polypeptide. |
| doi_str_mv | 10.1016/0896-6273(93)90202-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75735905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0896627393902023</els_id><sourcerecordid>17443613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-e9270949e4ecfac0e1b7c4cb0f67a4261130ebfd345a6f67ede3bb55b4fcc4e43</originalsourceid><addsrcrecordid>eNqFkVFr2zAQx8VYadNu32ADP4zSPriTrLMVvQxGaNNCS8fYnoUsnxMVR3Z1Tum-_WQS8tiC4ED3-x_H7xj7IviV4KL6zue6yqtCyQstLzUveJHLD2wmuFY5CK0_stkBOWGnRE-cCyi1OGbHqppDIWHGHn_3TWZDk7k-YDas-7GP6HBIJXPYdZTh6xCRKGs8jT64MVthQMraCVg-_MpXdsQUX9sQsKNP7Ki1HeHnfT1jf2-u_yxu8_vH5d3i533uYC7HHHWhuAaNgK61jqOolQNX87ZSFopKCMmxbhsJpa3SHzYo67osa2idAwR5xs53c4fYP2-RRrPxNC1sA_ZbMqpUstS8fBcUCkBWQiYQdqCLPVHE1gzRb2z8ZwQ3k3Az2TSTTaPTm4SbKfZ1P39bb7A5hPaGU__bvm_J2a6NNjhPBwyU5qLUCfuxw5JDfPEYDTmPwWHj0z1G0_T-7T3-AzKhnJo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17443613</pqid></control><display><type>article</type><title>Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Bönigk, Wolfgang ; Altenhofen, Wolfram ; Müller, Frank ; Dose, Andrea ; Illing, Michelle ; Molday, Robert S. ; Kaupp, U. Benjamin</creator><creatorcontrib>Bönigk, Wolfgang ; Altenhofen, Wolfram ; Müller, Frank ; Dose, Andrea ; Illing, Michelle ; Molday, Robert S. ; Kaupp, U. Benjamin</creatorcontrib><description>Signal transduction in vertebrate rod and cone photoreceptorcells involves ion channels that are directly gated by the internal messenger cGMP. Rods and each type of cones express genetically related yet different forms of photopigments. Enzymes that control the light-stimulated hydrolysis of cGMP in rods and cones are also the product of distinct genes. Two different cDNA clones encoding cGMP-gated channels have been characterized from the chicken retina. Expression of cDNAs in Xenopus oocytes gives rise to cGMP-stimulated channel activity. Antibodies against a synthetic peptide specific for the C-terminal amino acid sequence derived from one clone stain outer segments of cone but not rod photoreceptors. Therefore chicken rod and cone cells each express different forms of cGMP-gated channels that are genetically related to each other. Expression in COS-1 cells produces the complete form of both channel polypeptides, whereas Western blot analysis indicates that channels in outer segment membranes are present in a processed form that is significantly shorter than the full-length polypeptide.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/0896-6273(93)90202-3</identifier><identifier>PMID: 7684234</identifier><identifier>CODEN: NERNET</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Blotting, Northern ; Chemical Phenomena ; Chemistry, Physical ; Chickens ; Cyclic GMP - metabolism ; Cyclic GMP - pharmacology ; Cyclic Nucleotide-Gated Cation Channels ; DNA - genetics ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Ion Channel Gating - drug effects ; Ion Channels - chemistry ; Ion Channels - genetics ; Molecular Sequence Data ; Oocytes - metabolism ; Photoreceptor Cells - metabolism ; RNA, Messenger - metabolism ; Signal Transduction ; Vertebrates: nervous system and sense organs ; Xenopus</subject><ispartof>Neuron (Cambridge, Mass.), 1993-05, Vol.10 (5), p.865-877</ispartof><rights>1993 Cell Press</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-e9270949e4ecfac0e1b7c4cb0f67a4261130ebfd345a6f67ede3bb55b4fcc4e43</citedby><cites>FETCH-LOGICAL-c483t-e9270949e4ecfac0e1b7c4cb0f67a4261130ebfd345a6f67ede3bb55b4fcc4e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0896-6273(93)90202-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4790159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7684234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bönigk, Wolfgang</creatorcontrib><creatorcontrib>Altenhofen, Wolfram</creatorcontrib><creatorcontrib>Müller, Frank</creatorcontrib><creatorcontrib>Dose, Andrea</creatorcontrib><creatorcontrib>Illing, Michelle</creatorcontrib><creatorcontrib>Molday, Robert S.</creatorcontrib><creatorcontrib>Kaupp, U. Benjamin</creatorcontrib><title>Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Signal transduction in vertebrate rod and cone photoreceptorcells involves ion channels that are directly gated by the internal messenger cGMP. Rods and each type of cones express genetically related yet different forms of photopigments. Enzymes that control the light-stimulated hydrolysis of cGMP in rods and cones are also the product of distinct genes. Two different cDNA clones encoding cGMP-gated channels have been characterized from the chicken retina. Expression of cDNAs in Xenopus oocytes gives rise to cGMP-stimulated channel activity. Antibodies against a synthetic peptide specific for the C-terminal amino acid sequence derived from one clone stain outer segments of cone but not rod photoreceptors. Therefore chicken rod and cone cells each express different forms of cGMP-gated channels that are genetically related to each other. Expression in COS-1 cells produces the complete form of both channel polypeptides, whereas Western blot analysis indicates that channels in outer segment membranes are present in a processed form that is significantly shorter than the full-length polypeptide.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Chickens</subject><subject>Cyclic GMP - metabolism</subject><subject>Cyclic GMP - pharmacology</subject><subject>Cyclic Nucleotide-Gated Cation Channels</subject><subject>DNA - genetics</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Ion Channel Gating - drug effects</subject><subject>Ion Channels - chemistry</subject><subject>Ion Channels - genetics</subject><subject>Molecular Sequence Data</subject><subject>Oocytes - metabolism</subject><subject>Photoreceptor Cells - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Xenopus</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr2zAQx8VYadNu32ADP4zSPriTrLMVvQxGaNNCS8fYnoUsnxMVR3Z1Tum-_WQS8tiC4ED3-x_H7xj7IviV4KL6zue6yqtCyQstLzUveJHLD2wmuFY5CK0_stkBOWGnRE-cCyi1OGbHqppDIWHGHn_3TWZDk7k-YDas-7GP6HBIJXPYdZTh6xCRKGs8jT64MVthQMraCVg-_MpXdsQUX9sQsKNP7Ki1HeHnfT1jf2-u_yxu8_vH5d3i533uYC7HHHWhuAaNgK61jqOolQNX87ZSFopKCMmxbhsJpa3SHzYo67osa2idAwR5xs53c4fYP2-RRrPxNC1sA_ZbMqpUstS8fBcUCkBWQiYQdqCLPVHE1gzRb2z8ZwQ3k3Az2TSTTaPTm4SbKfZ1P39bb7A5hPaGU__bvm_J2a6NNjhPBwyU5qLUCfuxw5JDfPEYDTmPwWHj0z1G0_T-7T3-AzKhnJo</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Bönigk, Wolfgang</creator><creator>Altenhofen, Wolfram</creator><creator>Müller, Frank</creator><creator>Dose, Andrea</creator><creator>Illing, Michelle</creator><creator>Molday, Robert S.</creator><creator>Kaupp, U. Benjamin</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels</title><author>Bönigk, Wolfgang ; Altenhofen, Wolfram ; Müller, Frank ; Dose, Andrea ; Illing, Michelle ; Molday, Robert S. ; Kaupp, U. Benjamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-e9270949e4ecfac0e1b7c4cb0f67a4261130ebfd345a6f67ede3bb55b4fcc4e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Chickens</topic><topic>Cyclic GMP - metabolism</topic><topic>Cyclic GMP - pharmacology</topic><topic>Cyclic Nucleotide-Gated Cation Channels</topic><topic>DNA - genetics</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Ion Channel Gating - drug effects</topic><topic>Ion Channels - chemistry</topic><topic>Ion Channels - genetics</topic><topic>Molecular Sequence Data</topic><topic>Oocytes - metabolism</topic><topic>Photoreceptor Cells - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bönigk, Wolfgang</creatorcontrib><creatorcontrib>Altenhofen, Wolfram</creatorcontrib><creatorcontrib>Müller, Frank</creatorcontrib><creatorcontrib>Dose, Andrea</creatorcontrib><creatorcontrib>Illing, Michelle</creatorcontrib><creatorcontrib>Molday, Robert S.</creatorcontrib><creatorcontrib>Kaupp, U. Benjamin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bönigk, Wolfgang</au><au>Altenhofen, Wolfram</au><au>Müller, Frank</au><au>Dose, Andrea</au><au>Illing, Michelle</au><au>Molday, Robert S.</au><au>Kaupp, U. Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>10</volume><issue>5</issue><spage>865</spage><epage>877</epage><pages>865-877</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><coden>NERNET</coden><abstract>Signal transduction in vertebrate rod and cone photoreceptorcells involves ion channels that are directly gated by the internal messenger cGMP. Rods and each type of cones express genetically related yet different forms of photopigments. Enzymes that control the light-stimulated hydrolysis of cGMP in rods and cones are also the product of distinct genes. Two different cDNA clones encoding cGMP-gated channels have been characterized from the chicken retina. Expression of cDNAs in Xenopus oocytes gives rise to cGMP-stimulated channel activity. Antibodies against a synthetic peptide specific for the C-terminal amino acid sequence derived from one clone stain outer segments of cone but not rod photoreceptors. Therefore chicken rod and cone cells each express different forms of cGMP-gated channels that are genetically related to each other. Expression in COS-1 cells produces the complete form of both channel polypeptides, whereas Western blot analysis indicates that channels in outer segment membranes are present in a processed form that is significantly shorter than the full-length polypeptide.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>7684234</pmid><doi>10.1016/0896-6273(93)90202-3</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 1993-05, Vol.10 (5), p.865-877 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75735905 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Blotting, Northern Chemical Phenomena Chemistry, Physical Chickens Cyclic GMP - metabolism Cyclic GMP - pharmacology Cyclic Nucleotide-Gated Cation Channels DNA - genetics Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene Expression Ion Channel Gating - drug effects Ion Channels - chemistry Ion Channels - genetics Molecular Sequence Data Oocytes - metabolism Photoreceptor Cells - metabolism RNA, Messenger - metabolism Signal Transduction Vertebrates: nervous system and sense organs Xenopus |
| title | Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T13%3A13%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rod%20and%20cone%20photoreceptor%20cells%20express%20distinct%20genes%20for%20cGMP-gated%20channels&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=B%C3%B6nigk,%20Wolfgang&rft.date=1993-05-01&rft.volume=10&rft.issue=5&rft.spage=865&rft.epage=877&rft.pages=865-877&rft.issn=0896-6273&rft.eissn=1097-4199&rft.coden=NERNET&rft_id=info:doi/10.1016/0896-6273(93)90202-3&rft_dat=%3Cproquest_cross%3E17443613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17443613&rft_id=info:pmid/7684234&rft_els_id=0896627393902023&rfr_iscdi=true |