University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation
Prolongation of the safe period of ischemia of the heart is an efficient way to overcome donor organ shortage, as demonstrated in renal and hepatic transplantation. We present the results of a prospective, randomized study comparing preservation with University of Wisconsin solution (UWS) versus St....
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| Veröffentlicht in: | The Annals of thoracic surgery 1993-05, Vol.55 (5), p.1131-1137 |
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| container_end_page | 1137 |
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| container_issue | 5 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 55 |
| creator | Demertzis, Stefanos Wippermann, Jens Schaper, Jutta Wahlers, Thorsten Schäfers, Hans-Joachim Wagenbreth, Ingrid Hausen, Bernard Haverich, Axel |
| description | Prolongation of the safe period of ischemia of the heart is an efficient way to overcome donor organ shortage, as demonstrated in renal and hepatic transplantation. We present the results of a prospective, randomized study comparing preservation with University of Wisconsin solution (UWS) versus St. Thomas' Hospital solution (STS) in clinical heart transplantation. A total of 39 patients were enrolled in the study (n = 20 for UWS and n = 19 for STS). Hemodynamic, electron microscopic, and biochemical evaluation did not reveal any significant differences in postoperative myocardial performance. Only the number of intraoperative defibrillations (0.82 for UWS versus 1.7 for STS) and the rhythm stability after reperfusion (
13
/
20
UWS hearts versus
6
/
19
STS hearts in sinus rhythm) were significantly different. Heart preservation with UWS and STS appears to be of comparable efficacy at mean ischemic times of less than 4 hours. |
| doi_str_mv | 10.1016/0003-4975(93)90019-E |
| format | Article |
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13
/
20
UWS hearts versus
6
/
19
STS hearts in sinus rhythm) were significantly different. Heart preservation with UWS and STS appears to be of comparable efficacy at mean ischemic times of less than 4 hours.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/0003-4975(93)90019-E</identifier><identifier>PMID: 8494421</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Adenosine ; Adult ; Allopurinol ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Bicarbonates - administration & dosage ; Bicarbonates - therapeutic use ; Biological and medical sciences ; Calcium Chloride - administration & dosage ; Calcium Chloride - therapeutic use ; Cardiac Output ; Cardiac Pacing, Artificial ; Cardioplegic Solutions - administration & dosage ; Cardioplegic Solutions - therapeutic use ; Clinical death. Palliative care. Organ gift and preservation ; Coronary Circulation ; Creatine Kinase - blood ; Female ; Follow-Up Studies ; Glutathione ; Heart Transplantation - methods ; Heart Transplantation - pathology ; Humans ; Insulin ; Isoenzymes ; Isotonic Solutions - therapeutic use ; Magnesium - administration & dosage ; Magnesium - therapeutic use ; Male ; Medical sciences ; Monitoring, Intraoperative ; Myocardium - pathology ; Organ Preservation Solutions ; Potassium Chloride - administration & dosage ; Potassium Chloride - therapeutic use ; Prospective Studies ; Raffinose ; Ringer's Lactate ; Sodium Chloride - administration & dosage ; Sodium Chloride - therapeutic use ; Solutions - administration & dosage ; Solutions - therapeutic use ; Survival Rate ; Time Factors ; Tissue Preservation]]></subject><ispartof>The Annals of thoracic surgery, 1993-05, Vol.55 (5), p.1131-1137</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-f505ded107fe434fe4467e6034ab201576b58054d434c740542b309486f8a90b3</citedby><cites>FETCH-LOGICAL-c488t-f505ded107fe434fe4467e6034ab201576b58054d434c740542b309486f8a90b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4792915$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8494421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demertzis, Stefanos</creatorcontrib><creatorcontrib>Wippermann, Jens</creatorcontrib><creatorcontrib>Schaper, Jutta</creatorcontrib><creatorcontrib>Wahlers, Thorsten</creatorcontrib><creatorcontrib>Schäfers, Hans-Joachim</creatorcontrib><creatorcontrib>Wagenbreth, Ingrid</creatorcontrib><creatorcontrib>Hausen, Bernard</creatorcontrib><creatorcontrib>Haverich, Axel</creatorcontrib><title>University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Prolongation of the safe period of ischemia of the heart is an efficient way to overcome donor organ shortage, as demonstrated in renal and hepatic transplantation. We present the results of a prospective, randomized study comparing preservation with University of Wisconsin solution (UWS) versus St. Thomas' Hospital solution (STS) in clinical heart transplantation. A total of 39 patients were enrolled in the study (n = 20 for UWS and n = 19 for STS). Hemodynamic, electron microscopic, and biochemical evaluation did not reveal any significant differences in postoperative myocardial performance. Only the number of intraoperative defibrillations (0.82 for UWS versus 1.7 for STS) and the rhythm stability after reperfusion (
13
/
20
UWS hearts versus
6
/
19
STS hearts in sinus rhythm) were significantly different. Heart preservation with UWS and STS appears to be of comparable efficacy at mean ischemic times of less than 4 hours.</description><subject>Adenosine</subject><subject>Adult</subject><subject>Allopurinol</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Bicarbonates - administration & dosage</subject><subject>Bicarbonates - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Calcium Chloride - administration & dosage</subject><subject>Calcium Chloride - therapeutic use</subject><subject>Cardiac Output</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardioplegic Solutions - administration & dosage</subject><subject>Cardioplegic Solutions - therapeutic use</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Coronary Circulation</subject><subject>Creatine Kinase - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glutathione</subject><subject>Heart Transplantation - methods</subject><subject>Heart Transplantation - pathology</subject><subject>Humans</subject><subject>Insulin</subject><subject>Isoenzymes</subject><subject>Isotonic Solutions - therapeutic use</subject><subject>Magnesium - administration & dosage</subject><subject>Magnesium - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monitoring, Intraoperative</subject><subject>Myocardium - pathology</subject><subject>Organ Preservation Solutions</subject><subject>Potassium Chloride - administration & dosage</subject><subject>Potassium Chloride - therapeutic use</subject><subject>Prospective Studies</subject><subject>Raffinose</subject><subject>Ringer's Lactate</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Solutions - administration & dosage</subject><subject>Solutions - therapeutic use</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tissue Preservation</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSDfb_oMWdChtcnAqWZJtXQolbD4g0EMTehSyPCYqtrTV2Av595Gzyx5zkUZ6nxmkh5DPnF1yxqsfjDFRSF2rcy0uNGNcF5t3ZMWVKouqVPo9WR2RD-QM8V8-ljk-JaeN1FKWfEXMY_A7SOinZxp7-tejiwF9oMvljPTPdEkfnuJo8Tu9jbj1kx0oxmGefAy0j4k-zaMNtIthqcGmiW4TIKSdXZCP5KS3A8Knw74mj9ebh6vb4v73zd3Vr_vCyaaZil4x1UHHWd2DFDIvsqqhYkLatmRc1VWrGqZkl0NXy1yVrWBaNlXfWM1asSbf9nO3Kf6fAScz5q_AMNgAcUZTq1ookXWsidyDLkXEBL3ZJj_a9Gw4M4tXs0gzizSjhXn1aja57cth_tyO0B2bDiJz_vWQW3R26JMNzuMRk7UuNVcZ-7nHILvYeUgGnYfgoPMJ3GS66N9-xwvcrZO0</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Demertzis, Stefanos</creator><creator>Wippermann, Jens</creator><creator>Schaper, Jutta</creator><creator>Wahlers, Thorsten</creator><creator>Schäfers, Hans-Joachim</creator><creator>Wagenbreth, Ingrid</creator><creator>Hausen, Bernard</creator><creator>Haverich, Axel</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation</title><author>Demertzis, Stefanos ; Wippermann, Jens ; Schaper, Jutta ; Wahlers, Thorsten ; Schäfers, Hans-Joachim ; Wagenbreth, Ingrid ; Hausen, Bernard ; Haverich, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-f505ded107fe434fe4467e6034ab201576b58054d434c740542b309486f8a90b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenosine</topic><topic>Adult</topic><topic>Allopurinol</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Bicarbonates - administration & dosage</topic><topic>Bicarbonates - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Calcium Chloride - administration & dosage</topic><topic>Calcium Chloride - therapeutic use</topic><topic>Cardiac Output</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardioplegic Solutions - administration & dosage</topic><topic>Cardioplegic Solutions - therapeutic use</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>Coronary Circulation</topic><topic>Creatine Kinase - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glutathione</topic><topic>Heart Transplantation - methods</topic><topic>Heart Transplantation - pathology</topic><topic>Humans</topic><topic>Insulin</topic><topic>Isoenzymes</topic><topic>Isotonic Solutions - therapeutic use</topic><topic>Magnesium - administration & dosage</topic><topic>Magnesium - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monitoring, Intraoperative</topic><topic>Myocardium - pathology</topic><topic>Organ Preservation Solutions</topic><topic>Potassium Chloride - administration & dosage</topic><topic>Potassium Chloride - therapeutic use</topic><topic>Prospective Studies</topic><topic>Raffinose</topic><topic>Ringer's Lactate</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Solutions - administration & dosage</topic><topic>Solutions - therapeutic use</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Tissue Preservation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demertzis, Stefanos</creatorcontrib><creatorcontrib>Wippermann, Jens</creatorcontrib><creatorcontrib>Schaper, Jutta</creatorcontrib><creatorcontrib>Wahlers, Thorsten</creatorcontrib><creatorcontrib>Schäfers, Hans-Joachim</creatorcontrib><creatorcontrib>Wagenbreth, Ingrid</creatorcontrib><creatorcontrib>Hausen, Bernard</creatorcontrib><creatorcontrib>Haverich, Axel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demertzis, Stefanos</au><au>Wippermann, Jens</au><au>Schaper, Jutta</au><au>Wahlers, Thorsten</au><au>Schäfers, Hans-Joachim</au><au>Wagenbreth, Ingrid</au><au>Hausen, Bernard</au><au>Haverich, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>55</volume><issue>5</issue><spage>1131</spage><epage>1137</epage><pages>1131-1137</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Prolongation of the safe period of ischemia of the heart is an efficient way to overcome donor organ shortage, as demonstrated in renal and hepatic transplantation. We present the results of a prospective, randomized study comparing preservation with University of Wisconsin solution (UWS) versus St. Thomas' Hospital solution (STS) in clinical heart transplantation. A total of 39 patients were enrolled in the study (n = 20 for UWS and n = 19 for STS). Hemodynamic, electron microscopic, and biochemical evaluation did not reveal any significant differences in postoperative myocardial performance. Only the number of intraoperative defibrillations (0.82 for UWS versus 1.7 for STS) and the rhythm stability after reperfusion (
13
/
20
UWS hearts versus
6
/
19
STS hearts in sinus rhythm) were significantly different. Heart preservation with UWS and STS appears to be of comparable efficacy at mean ischemic times of less than 4 hours.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8494421</pmid><doi>10.1016/0003-4975(93)90019-E</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4975 |
| ispartof | The Annals of thoracic surgery, 1993-05, Vol.55 (5), p.1131-1137 |
| issn | 0003-4975 1552-6259 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenosine Adult Allopurinol Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bicarbonates - administration & dosage Bicarbonates - therapeutic use Biological and medical sciences Calcium Chloride - administration & dosage Calcium Chloride - therapeutic use Cardiac Output Cardiac Pacing, Artificial Cardioplegic Solutions - administration & dosage Cardioplegic Solutions - therapeutic use Clinical death. Palliative care. Organ gift and preservation Coronary Circulation Creatine Kinase - blood Female Follow-Up Studies Glutathione Heart Transplantation - methods Heart Transplantation - pathology Humans Insulin Isoenzymes Isotonic Solutions - therapeutic use Magnesium - administration & dosage Magnesium - therapeutic use Male Medical sciences Monitoring, Intraoperative Myocardium - pathology Organ Preservation Solutions Potassium Chloride - administration & dosage Potassium Chloride - therapeutic use Prospective Studies Raffinose Ringer's Lactate Sodium Chloride - administration & dosage Sodium Chloride - therapeutic use Solutions - administration & dosage Solutions - therapeutic use Survival Rate Time Factors Tissue Preservation |
| title | University of Wisconsin versus St. Thomas' Hospital solution for human donor heart preservation |
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