Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum

The aim of this study was to compare dopamine receptor binding affinities of all currently approved dopamine receptor agonist treatments for Parkinson's disease (PD) in human brain tissue. Alpha-dihydroergocryptine and lisuride displayed higher comparative affinities (Ki=35.4 and 56.7 nM, respe...

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Veröffentlicht in:	Journal of Neural Transmission 2003-10, Vol.110 (10), p.1119-1127
Hauptverfasser:	GERLACH, M, DOUBLE, K, ARZBERGER, T, LEBLHUBER, F, TATSCHNER, T, RIEDERER, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Autopsy Biological and medical sciences Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Agonists - metabolism Dopamine Agonists - therapeutic use Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Middle Aged Neurology Parkinson Disease - drug therapy Receptors, Dopamine - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 Vertebrates: nervous system and sense organs
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