The role of protein tyrosine phosphatases in density-dependent growth control of normal rat kidney cells

In normal rat kidney cells protein tyrosine phosphatases (PTPases) play a role in attaining density-dependent growth arrest after stimulation with mitogens. The PTPase inhibitor sodium orthovanadate prevents density-dependent growth inhibition of EGF-treated cells and mimicks in that respect the act...

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Veröffentlicht in:	FEBS letters 1993-05, Vol.322 (1), p.83-87
Hauptverfasser:	Rijksen, Gert, Völler, Maureen C.W., van Zoelen, Everardus J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Count Cell cycle, cell proliferation Cell Division Cell physiology Cells, Cultured Density-dependent growth inhibition EGF epidermal growth factor Fundamental and applied biological sciences. Psychology Kidney - cytology Kidney - drug effects Kidney - enzymology Molecular and cellular biology normal rat kidney Normal rat kidney cell NRK PDGP platelet-derived growth factor Protein tyrosine phosphatase Protein Tyrosine Phosphatases - metabolism PTPase Rats Retinoic acid Signal Transduction TGFβ Transforming Growth Factor beta - pharmacology Transforming growth factor-β Tretinoin - pharmacology Vanadate Vanadates - pharmacology
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