Schnabel cavernous degeneration: a vascular change of the aging eye
Schnabel cavernous degeneration is a histologic finding originally attributed to glaucoma; however, its cause and significance have been controversial. To determine the basic cause of the formation of cavernous spaces in the proximal optic nerve and its clinical significance. A retrospective analysi...
Gespeichert in:
Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2003-10, Vol.127 (10), p.1314-1319 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1319 |
---|---|
container_issue | 10 |
container_start_page | 1314 |
container_title | Archives of pathology & laboratory medicine (1976) |
container_volume | 127 |
creator | Giarelli, Luigi Falconieri, Giovanni Cameron, J Douglas Pheley, Alfred M |
description | Schnabel cavernous degeneration is a histologic finding originally attributed to glaucoma; however, its cause and significance have been controversial.
To determine the basic cause of the formation of cavernous spaces in the proximal optic nerve and its clinical significance.
A retrospective analysis of 4500 autopsy eyes processed for histologic evaluation between 1967 and 1991.
Ninety-three (2.1% of eyes examined) cases of Schnabel cavernous optic atrophy were identified. The majority of the eyes were from women (81%). The mean age of the entire group was 88 years (reference range, 54-103 years). Severe vascular anomalies were present in 75% of the individuals. Cavernous degeneration was unilateral in 82% of the cases. Loss of ganglion cells and nerve fiber layer consistent with glaucoma was found in 23.7% of the individuals. Clinical information was available for 15 individuals (16%). Half of them were thought to have some clinical optic nerve damage; in the remainder, no specific optic disc abnormalities were noted. Histologic findings of arteriolosclerosis in the optic nerve circulation were common. The prevalence of glaucoma was low.
Schnabel cavernous optic atrophy appears to be a unilateral condition of elderly women with systemic vascular disease and few characteristic ocular features. Our data indicate that a chronic vascular occlusive disease of the proximal optic nerve is more involved in cavernous atrophic pathogenesis than is a sustained increase of intraocular pressure. |
doi_str_mv | 10.5858/2003-127-1314-SCDAVC |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75734277</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>443392791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-c8a6eb93c9f10f1cd1f77aed195db9425eb7ce9696d31e0c216b7cbaaa3104c93</originalsourceid><addsrcrecordid>eNpdkE1Lw0AQhhdRbK3-A5HFg7fozn4kXW8lfkLBQ9XrstlM-kGa1N2k0H_vlhYET8MMzzvMPIRcA7tXYzV-4IyJBHiWgACZzPKnyXd-QoagpEg4pOqUDNke0XqsBuQihFVsNedwTgYgFQeZyiHJZ27R2AJr6uwWfdP2gZY4xwa97ZZt80gt3drg-tp66ha2mSNtK9otkNr5splT3OElOatsHfDqWEfk6-X5M39Lph-v7_lkmjghWJe4sU2x0MLpClgFroQqyyyWoFVZaMkVFplDneq0FIDMxSfioLDWCmDSaTEid4e9G9_-9Bg6s14Gh3VtG4x3m0xlQvIsi-DtP3DV9r6JtxkOoIUQXERIHiDn2xA8Vmbjl2vrdwaY2Rs2e8MmGjZ7w-ZgOMZujrv7Yo3lX-ioVPwCKXB2mg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211933323</pqid></control><display><type>article</type><title>Schnabel cavernous degeneration: a vascular change of the aging eye</title><source>MEDLINE</source><source>Allen Press Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Giarelli, Luigi ; Falconieri, Giovanni ; Cameron, J Douglas ; Pheley, Alfred M</creator><creatorcontrib>Giarelli, Luigi ; Falconieri, Giovanni ; Cameron, J Douglas ; Pheley, Alfred M</creatorcontrib><description>Schnabel cavernous degeneration is a histologic finding originally attributed to glaucoma; however, its cause and significance have been controversial.
To determine the basic cause of the formation of cavernous spaces in the proximal optic nerve and its clinical significance.
A retrospective analysis of 4500 autopsy eyes processed for histologic evaluation between 1967 and 1991.
Ninety-three (2.1% of eyes examined) cases of Schnabel cavernous optic atrophy were identified. The majority of the eyes were from women (81%). The mean age of the entire group was 88 years (reference range, 54-103 years). Severe vascular anomalies were present in 75% of the individuals. Cavernous degeneration was unilateral in 82% of the cases. Loss of ganglion cells and nerve fiber layer consistent with glaucoma was found in 23.7% of the individuals. Clinical information was available for 15 individuals (16%). Half of them were thought to have some clinical optic nerve damage; in the remainder, no specific optic disc abnormalities were noted. Histologic findings of arteriolosclerosis in the optic nerve circulation were common. The prevalence of glaucoma was low.
Schnabel cavernous optic atrophy appears to be a unilateral condition of elderly women with systemic vascular disease and few characteristic ocular features. Our data indicate that a chronic vascular occlusive disease of the proximal optic nerve is more involved in cavernous atrophic pathogenesis than is a sustained increase of intraocular pressure.</description><identifier>ISSN: 0003-9985</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/2003-127-1314-SCDAVC</identifier><identifier>PMID: 14521464</identifier><identifier>CODEN: APLMAS</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Acids ; Aged ; Aging ; Autopsies ; Blood Vessels - abnormalities ; Female ; Glaucoma ; Humans ; Male ; Middle Aged ; Optic Atrophy - diagnosis ; Optic Atrophy - etiology ; Optic Atrophy - pathology ; Optic nerve ; Optic Nerve - blood supply ; Optic Nerve - pathology ; Retrospective Studies ; Systemic diseases ; Womens health</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2003-10, Vol.127 (10), p.1314-1319</ispartof><rights>Copyright College of American Pathologists Oct 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-c8a6eb93c9f10f1cd1f77aed195db9425eb7ce9696d31e0c216b7cbaaa3104c93</citedby><cites>FETCH-LOGICAL-c330t-c8a6eb93c9f10f1cd1f77aed195db9425eb7ce9696d31e0c216b7cbaaa3104c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14521464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giarelli, Luigi</creatorcontrib><creatorcontrib>Falconieri, Giovanni</creatorcontrib><creatorcontrib>Cameron, J Douglas</creatorcontrib><creatorcontrib>Pheley, Alfred M</creatorcontrib><title>Schnabel cavernous degeneration: a vascular change of the aging eye</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>Schnabel cavernous degeneration is a histologic finding originally attributed to glaucoma; however, its cause and significance have been controversial.
To determine the basic cause of the formation of cavernous spaces in the proximal optic nerve and its clinical significance.
A retrospective analysis of 4500 autopsy eyes processed for histologic evaluation between 1967 and 1991.
Ninety-three (2.1% of eyes examined) cases of Schnabel cavernous optic atrophy were identified. The majority of the eyes were from women (81%). The mean age of the entire group was 88 years (reference range, 54-103 years). Severe vascular anomalies were present in 75% of the individuals. Cavernous degeneration was unilateral in 82% of the cases. Loss of ganglion cells and nerve fiber layer consistent with glaucoma was found in 23.7% of the individuals. Clinical information was available for 15 individuals (16%). Half of them were thought to have some clinical optic nerve damage; in the remainder, no specific optic disc abnormalities were noted. Histologic findings of arteriolosclerosis in the optic nerve circulation were common. The prevalence of glaucoma was low.
Schnabel cavernous optic atrophy appears to be a unilateral condition of elderly women with systemic vascular disease and few characteristic ocular features. Our data indicate that a chronic vascular occlusive disease of the proximal optic nerve is more involved in cavernous atrophic pathogenesis than is a sustained increase of intraocular pressure.</description><subject>Acids</subject><subject>Aged</subject><subject>Aging</subject><subject>Autopsies</subject><subject>Blood Vessels - abnormalities</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Optic Atrophy - diagnosis</subject><subject>Optic Atrophy - etiology</subject><subject>Optic Atrophy - pathology</subject><subject>Optic nerve</subject><subject>Optic Nerve - blood supply</subject><subject>Optic Nerve - pathology</subject><subject>Retrospective Studies</subject><subject>Systemic diseases</subject><subject>Womens health</subject><issn>0003-9985</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1Lw0AQhhdRbK3-A5HFg7fozn4kXW8lfkLBQ9XrstlM-kGa1N2k0H_vlhYET8MMzzvMPIRcA7tXYzV-4IyJBHiWgACZzPKnyXd-QoagpEg4pOqUDNke0XqsBuQihFVsNedwTgYgFQeZyiHJZ27R2AJr6uwWfdP2gZY4xwa97ZZt80gt3drg-tp66ha2mSNtK9otkNr5splT3OElOatsHfDqWEfk6-X5M39Lph-v7_lkmjghWJe4sU2x0MLpClgFroQqyyyWoFVZaMkVFplDneq0FIDMxSfioLDWCmDSaTEid4e9G9_-9Bg6s14Gh3VtG4x3m0xlQvIsi-DtP3DV9r6JtxkOoIUQXERIHiDn2xA8Vmbjl2vrdwaY2Rs2e8MmGjZ7w-ZgOMZujrv7Yo3lX-ioVPwCKXB2mg</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Giarelli, Luigi</creator><creator>Falconieri, Giovanni</creator><creator>Cameron, J Douglas</creator><creator>Pheley, Alfred M</creator><general>College of American Pathologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Schnabel cavernous degeneration: a vascular change of the aging eye</title><author>Giarelli, Luigi ; Falconieri, Giovanni ; Cameron, J Douglas ; Pheley, Alfred M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-c8a6eb93c9f10f1cd1f77aed195db9425eb7ce9696d31e0c216b7cbaaa3104c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acids</topic><topic>Aged</topic><topic>Aging</topic><topic>Autopsies</topic><topic>Blood Vessels - abnormalities</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Optic Atrophy - diagnosis</topic><topic>Optic Atrophy - etiology</topic><topic>Optic Atrophy - pathology</topic><topic>Optic nerve</topic><topic>Optic Nerve - blood supply</topic><topic>Optic Nerve - pathology</topic><topic>Retrospective Studies</topic><topic>Systemic diseases</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giarelli, Luigi</creatorcontrib><creatorcontrib>Falconieri, Giovanni</creatorcontrib><creatorcontrib>Cameron, J Douglas</creatorcontrib><creatorcontrib>Pheley, Alfred M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giarelli, Luigi</au><au>Falconieri, Giovanni</au><au>Cameron, J Douglas</au><au>Pheley, Alfred M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schnabel cavernous degeneration: a vascular change of the aging eye</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2003-10</date><risdate>2003</risdate><volume>127</volume><issue>10</issue><spage>1314</spage><epage>1319</epage><pages>1314-1319</pages><issn>0003-9985</issn><eissn>1543-2165</eissn><coden>APLMAS</coden><abstract>Schnabel cavernous degeneration is a histologic finding originally attributed to glaucoma; however, its cause and significance have been controversial.
To determine the basic cause of the formation of cavernous spaces in the proximal optic nerve and its clinical significance.
A retrospective analysis of 4500 autopsy eyes processed for histologic evaluation between 1967 and 1991.
Ninety-three (2.1% of eyes examined) cases of Schnabel cavernous optic atrophy were identified. The majority of the eyes were from women (81%). The mean age of the entire group was 88 years (reference range, 54-103 years). Severe vascular anomalies were present in 75% of the individuals. Cavernous degeneration was unilateral in 82% of the cases. Loss of ganglion cells and nerve fiber layer consistent with glaucoma was found in 23.7% of the individuals. Clinical information was available for 15 individuals (16%). Half of them were thought to have some clinical optic nerve damage; in the remainder, no specific optic disc abnormalities were noted. Histologic findings of arteriolosclerosis in the optic nerve circulation were common. The prevalence of glaucoma was low.
Schnabel cavernous optic atrophy appears to be a unilateral condition of elderly women with systemic vascular disease and few characteristic ocular features. Our data indicate that a chronic vascular occlusive disease of the proximal optic nerve is more involved in cavernous atrophic pathogenesis than is a sustained increase of intraocular pressure.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>14521464</pmid><doi>10.5858/2003-127-1314-SCDAVC</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0003-9985 |
ispartof | Archives of pathology & laboratory medicine (1976), 2003-10, Vol.127 (10), p.1314-1319 |
issn | 0003-9985 1543-2165 |
language | eng |
recordid | cdi_proquest_miscellaneous_75734277 |
source | MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals |
subjects | Acids Aged Aging Autopsies Blood Vessels - abnormalities Female Glaucoma Humans Male Middle Aged Optic Atrophy - diagnosis Optic Atrophy - etiology Optic Atrophy - pathology Optic nerve Optic Nerve - blood supply Optic Nerve - pathology Retrospective Studies Systemic diseases Womens health |
title | Schnabel cavernous degeneration: a vascular change of the aging eye |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T17%3A16%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Schnabel%20cavernous%20degeneration:%20a%20vascular%20change%20of%20the%20aging%20eye&rft.jtitle=Archives%20of%20pathology%20&%20laboratory%20medicine%20(1976)&rft.au=Giarelli,%20Luigi&rft.date=2003-10&rft.volume=127&rft.issue=10&rft.spage=1314&rft.epage=1319&rft.pages=1314-1319&rft.issn=0003-9985&rft.eissn=1543-2165&rft.coden=APLMAS&rft_id=info:doi/10.5858/2003-127-1314-SCDAVC&rft_dat=%3Cproquest_cross%3E443392791%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211933323&rft_id=info:pmid/14521464&rfr_iscdi=true |