Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning
The expression of the gamma protein kinase C isoenzyme (PKCγ) and of the c- fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-relate...
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| Veröffentlicht in: | Brain research 1993-03, Vol.606 (2), p.315-318 |
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| creator | Ambalavanar, R. Van der Zee, E.A. Bolhuis, J.J. McCabe, B.J. Horn, G. |
| description | The expression of the gamma protein kinase C isoenzyme (PKCγ) and of the c-
fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-related increase in the expression of Fos in the IMHV of the chick after imprinting; (b) PKCγ is expressed in neurones in most regions of the chick forebrain, including the IMHV. In the present study it was found that in imprinted chicks, 96.5% of neurones in the IMHV that expressed Fos also stained positively for PKCγ. These results raise the possibility of a functional connection between PKCγ activation and c-
fos expression in neurones in general, and in particular in neurones in the IMHV that are involved in learning. |
| doi_str_mv | 10.1016/0006-8993(93)91000-I |
| format | Article |
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fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-related increase in the expression of Fos in the IMHV of the chick after imprinting; (b) PKCγ is expressed in neurones in most regions of the chick forebrain, including the IMHV. In the present study it was found that in imprinted chicks, 96.5% of neurones in the IMHV that expressed Fos also stained positively for PKCγ. These results raise the possibility of a functional connection between PKCγ activation and c-
fos expression in neurones in general, and in particular in neurones in the IMHV that are involved in learning.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)91000-I</identifier><identifier>PMID: 8490724</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Antibodies, Monoclonal ; Biochemistry and metabolism ; Biological and medical sciences ; c- fos ; Cell Nucleus - metabolism ; Central nervous system ; Chick ; Chickens ; Fos protein ; Fundamental and applied biological sciences. Psychology ; Imprinting ; Intermediate and medial hyperstriatum ventrale ; Isoenzymes - metabolism ; Learning ; Learning - physiology ; Neurons - metabolism ; Protein kinase C ; Protein Kinase C - metabolism ; Protein kinase Cγ ; Proto-Oncogene Proteins c-fos - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1993-03, Vol.606 (2), p.315-318</ispartof><rights>1993 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-7ea490cbb80cd1ad2d3aeda5934efcb808ad6300c5f23920ecc07a63462faf1d3</citedby><cites>FETCH-LOGICAL-c301t-7ea490cbb80cd1ad2d3aeda5934efcb808ad6300c5f23920ecc07a63462faf1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000689939391000I$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4637557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8490724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambalavanar, R.</creatorcontrib><creatorcontrib>Van der Zee, E.A.</creatorcontrib><creatorcontrib>Bolhuis, J.J.</creatorcontrib><creatorcontrib>McCabe, B.J.</creatorcontrib><creatorcontrib>Horn, G.</creatorcontrib><title>Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The expression of the gamma protein kinase C isoenzyme (PKCγ) and of the c-
fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-related increase in the expression of Fos in the IMHV of the chick after imprinting; (b) PKCγ is expressed in neurones in most regions of the chick forebrain, including the IMHV. In the present study it was found that in imprinted chicks, 96.5% of neurones in the IMHV that expressed Fos also stained positively for PKCγ. These results raise the possibility of a functional connection between PKCγ activation and c-
fos expression in neurones in general, and in particular in neurones in the IMHV that are involved in learning.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>c- fos</subject><subject>Cell Nucleus - metabolism</subject><subject>Central nervous system</subject><subject>Chick</subject><subject>Chickens</subject><subject>Fos protein</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Imprinting</subject><subject>Intermediate and medial hyperstriatum ventrale</subject><subject>Isoenzymes - metabolism</subject><subject>Learning</subject><subject>Learning - physiology</subject><subject>Neurons - metabolism</subject><subject>Protein kinase C</subject><subject>Protein Kinase C - metabolism</subject><subject>Protein kinase Cγ</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1uFDEMjhBVWRbeAKQcEGoPA8lkfntAQitKV60EBzhH3sRTBWaSbTyzYp-Ch-E9-kxk2NUekSxZtj9_tj8z9kqKd1LI6r0QosqatlUXrbpsZQqz9RO2kE2dZ1VeiKdscYI8Y8-JfqRQqVacs_OmaEWdFwv2exUy_LWNSOSC56Hj14G4G4bJh4hgRrdz4547z7cxjJj8T-eBkF98vV09_rnMtoFcAiH3OMXgka74wwR-dCP8S4OHfk-OZmrgmwiJIuL9PMz5Xeh3aGf2HiF65-9fsLMOesKXR79k368_fVvdZHdfPq9XH-8yo4QcsxohXWA2m0YYK8HmVgFaKFtVYGdStgFbKSFM2eWqzQUaI2qoVFHlHXTSqiV7e-BNZz1MSKMeHBnse_AYJtJ1WSepyioBiwPQxEAUsdPb6AaIey2Fnv-gZ5H1LLKebf6DXqe210f-aTOgPTUdhU_1N8c6kIG-i-CNoxOsqFRdphWW7MMBhkmLncOoyTj0Bq2LaEZtg_v_Hn8Bs_aoYg</recordid><startdate>19930326</startdate><enddate>19930326</enddate><creator>Ambalavanar, R.</creator><creator>Van der Zee, E.A.</creator><creator>Bolhuis, J.J.</creator><creator>McCabe, B.J.</creator><creator>Horn, G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930326</creationdate><title>Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning</title><author>Ambalavanar, R. ; Van der Zee, E.A. ; Bolhuis, J.J. ; McCabe, B.J. ; Horn, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-7ea490cbb80cd1ad2d3aeda5934efcb808ad6300c5f23920ecc07a63462faf1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>c- fos</topic><topic>Cell Nucleus - metabolism</topic><topic>Central nervous system</topic><topic>Chick</topic><topic>Chickens</topic><topic>Fos protein</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Imprinting</topic><topic>Intermediate and medial hyperstriatum ventrale</topic><topic>Isoenzymes - metabolism</topic><topic>Learning</topic><topic>Learning - physiology</topic><topic>Neurons - metabolism</topic><topic>Protein kinase C</topic><topic>Protein Kinase C - metabolism</topic><topic>Protein kinase Cγ</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambalavanar, R.</creatorcontrib><creatorcontrib>Van der Zee, E.A.</creatorcontrib><creatorcontrib>Bolhuis, J.J.</creatorcontrib><creatorcontrib>McCabe, B.J.</creatorcontrib><creatorcontrib>Horn, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambalavanar, R.</au><au>Van der Zee, E.A.</au><au>Bolhuis, J.J.</au><au>McCabe, B.J.</au><au>Horn, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1993-03-26</date><risdate>1993</risdate><volume>606</volume><issue>2</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The expression of the gamma protein kinase C isoenzyme (PKCγ) and of the c-
fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-related increase in the expression of Fos in the IMHV of the chick after imprinting; (b) PKCγ is expressed in neurones in most regions of the chick forebrain, including the IMHV. In the present study it was found that in imprinted chicks, 96.5% of neurones in the IMHV that expressed Fos also stained positively for PKCγ. These results raise the possibility of a functional connection between PKCγ activation and c-
fos expression in neurones in general, and in particular in neurones in the IMHV that are involved in learning.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8490724</pmid><doi>10.1016/0006-8993(93)91000-I</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antibodies, Monoclonal Biochemistry and metabolism Biological and medical sciences c- fos Cell Nucleus - metabolism Central nervous system Chick Chickens Fos protein Fundamental and applied biological sciences. Psychology Imprinting Intermediate and medial hyperstriatum ventrale Isoenzymes - metabolism Learning Learning - physiology Neurons - metabolism Protein kinase C Protein Kinase C - metabolism Protein kinase Cγ Proto-Oncogene Proteins c-fos - metabolism Vertebrates: nervous system and sense organs |
| title | Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning |
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