Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae
The efficacy of a high dose of ivermectin (1.0 mg per kg Eqvalan liquid drench) on encysted cyathostomes was tested in a controlled study using 12 adult ponies with naturally acquired cyathostome infections. Six treated ponies and six non-treated controls were held in separate stalls for a period of...
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| Veröffentlicht in: | Veterinary parasitology 1993-03, Vol.47 (1), p.99-106 |
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| creator | Klei, T.R. Chapman, M.R. French, D.D. Taylor, H.W. |
| description | The efficacy of a high dose of ivermectin (1.0 mg per kg Eqvalan liquid drench) on encysted cyathostomes was tested in a controlled study using 12 adult ponies with naturally acquired cyathostome infections. Six treated ponies and six non-treated controls were held in separate stalls for a period of 5 weeks. Cyathostome burdens, which included lumenal larvae, adults and encysted larvae, were determined at necropsy. The viability of encysted larvae, based on morphologic integrity, was assessed by observation of mural transillumination and by the histologic appearance of 12 larvae per pony. Efficacy against adult cyathostomes was 99.9%. Lumenal cyathostome larval numbers were reduced by 87%. Numbers of encysted cyathostome larvae, identified by transillumination of the large intestine, were reduced by 35%. However, this reduction was not statistically significant (
P > 0.05) and differences in viability of encysted larvae were not observed. The data strongly indicated that ivermectin has little demonstrable effect on encysted equine cyathostomes. |
| doi_str_mv | 10.1016/0304-4017(93)90180-U |
| format | Article |
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P > 0.05) and differences in viability of encysted larvae were not observed. The data strongly indicated that ivermectin has little demonstrable effect on encysted equine cyathostomes.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/0304-4017(93)90180-U</identifier><identifier>PMID: 8493773</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; ANTHELMINTHIQUE ; ANTHELMINTICS ; ANTIHELMINTICOS ; Evaluation Studies as Topic ; Female ; Horse Diseases - drug therapy ; Horse Diseases - parasitology ; Horses ; INSPECCION POSTMORTEM ; IVERMECTIN ; Ivermectin - therapeutic use ; IVERMECTINA ; IVERMECTINE ; Larva - drug effects ; LARVAE ; LARVAS ; LARVE ; NECROPSIE ; NEMATODA ; PONEY ; PONIES ; POSTMORTEM EXAMINATION ; Strongylida - drug effects ; Strongylida Infections - drug therapy ; Strongylida Infections - parasitology ; Strongylida Infections - veterinary</subject><ispartof>Veterinary parasitology, 1993-03, Vol.47 (1), p.99-106</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-c89b288ee4210bce24801356d99721cb844b1cf7584f803284bcfde56f7412103</citedby><cites>FETCH-LOGICAL-c442t-c89b288ee4210bce24801356d99721cb844b1cf7584f803284bcfde56f7412103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030440179390180U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8493773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klei, T.R.</creatorcontrib><creatorcontrib>Chapman, M.R.</creatorcontrib><creatorcontrib>French, D.D.</creatorcontrib><creatorcontrib>Taylor, H.W.</creatorcontrib><title>Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>The efficacy of a high dose of ivermectin (1.0 mg per kg Eqvalan liquid drench) on encysted cyathostomes was tested in a controlled study using 12 adult ponies with naturally acquired cyathostome infections. Six treated ponies and six non-treated controls were held in separate stalls for a period of 5 weeks. Cyathostome burdens, which included lumenal larvae, adults and encysted larvae, were determined at necropsy. The viability of encysted larvae, based on morphologic integrity, was assessed by observation of mural transillumination and by the histologic appearance of 12 larvae per pony. Efficacy against adult cyathostomes was 99.9%. Lumenal cyathostome larval numbers were reduced by 87%. Numbers of encysted cyathostome larvae, identified by transillumination of the large intestine, were reduced by 35%. However, this reduction was not statistically significant (
P > 0.05) and differences in viability of encysted larvae were not observed. The data strongly indicated that ivermectin has little demonstrable effect on encysted equine cyathostomes.</description><subject>Animals</subject><subject>ANTHELMINTHIQUE</subject><subject>ANTHELMINTICS</subject><subject>ANTIHELMINTICOS</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Horse Diseases - drug therapy</subject><subject>Horse Diseases - parasitology</subject><subject>Horses</subject><subject>INSPECCION POSTMORTEM</subject><subject>IVERMECTIN</subject><subject>Ivermectin - therapeutic use</subject><subject>IVERMECTINA</subject><subject>IVERMECTINE</subject><subject>Larva - drug effects</subject><subject>LARVAE</subject><subject>LARVAS</subject><subject>LARVE</subject><subject>NECROPSIE</subject><subject>NEMATODA</subject><subject>PONEY</subject><subject>PONIES</subject><subject>POSTMORTEM EXAMINATION</subject><subject>Strongylida - drug effects</subject><subject>Strongylida Infections - drug therapy</subject><subject>Strongylida Infections - parasitology</subject><subject>Strongylida Infections - veterinary</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSLbb_oHSgk6hObgZfdiSL4US0iawpJcsPQpZHqcKtpVIsmH_fbzdJcecBuaZ9x14CPnC4DsDVl2CAFlIYOpbLS5qYBqK7TuyYlqJgpclvCer15Mz8iGlRwCQUKlTcqplLZQSK_L3erb9ZLMPIw0d9TPGAV32I7WZ2pFij7PN2NI2JKT2wfoxZYqj26X9Fp8nPyJ1O5v_hZTDgLS3cbb4kZx0tk_46TjXZPvr-v7qptj8-X179XNTOCl5LpyuG641ouQMGodcamCirNq6Vpy5RkvZMNepUstOg-BaNq5rsaw6JdkSEWtyfuh9iuF5wpTN4JPDvrcjhikZVSoh-NK5JvJw6GJIKWJnnqIfbNwZBmbv0-xlmb0sUwvz36fZLrGvx_6pGbB9DR0FLvzzgXc2GPsQfTJ3m1oA16xa4I8DxMXA7DGa5PziDlsfF8mmDf7t7y_WNoy1</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Klei, T.R.</creator><creator>Chapman, M.R.</creator><creator>French, D.D.</creator><creator>Taylor, H.W.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae</title><author>Klei, T.R. ; Chapman, M.R. ; French, D.D. ; Taylor, H.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c89b288ee4210bce24801356d99721cb844b1cf7584f803284bcfde56f7412103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>ANTHELMINTHIQUE</topic><topic>ANTHELMINTICS</topic><topic>ANTIHELMINTICOS</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Horse Diseases - drug therapy</topic><topic>Horse Diseases - parasitology</topic><topic>Horses</topic><topic>INSPECCION POSTMORTEM</topic><topic>IVERMECTIN</topic><topic>Ivermectin - therapeutic use</topic><topic>IVERMECTINA</topic><topic>IVERMECTINE</topic><topic>Larva - drug effects</topic><topic>LARVAE</topic><topic>LARVAS</topic><topic>LARVE</topic><topic>NECROPSIE</topic><topic>NEMATODA</topic><topic>PONEY</topic><topic>PONIES</topic><topic>POSTMORTEM EXAMINATION</topic><topic>Strongylida - drug effects</topic><topic>Strongylida Infections - drug therapy</topic><topic>Strongylida Infections - parasitology</topic><topic>Strongylida Infections - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klei, T.R.</creatorcontrib><creatorcontrib>Chapman, M.R.</creatorcontrib><creatorcontrib>French, D.D.</creatorcontrib><creatorcontrib>Taylor, H.W.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klei, T.R.</au><au>Chapman, M.R.</au><au>French, D.D.</au><au>Taylor, H.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>47</volume><issue>1</issue><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>The efficacy of a high dose of ivermectin (1.0 mg per kg Eqvalan liquid drench) on encysted cyathostomes was tested in a controlled study using 12 adult ponies with naturally acquired cyathostome infections. Six treated ponies and six non-treated controls were held in separate stalls for a period of 5 weeks. Cyathostome burdens, which included lumenal larvae, adults and encysted larvae, were determined at necropsy. The viability of encysted larvae, based on morphologic integrity, was assessed by observation of mural transillumination and by the histologic appearance of 12 larvae per pony. Efficacy against adult cyathostomes was 99.9%. Lumenal cyathostome larval numbers were reduced by 87%. Numbers of encysted cyathostome larvae, identified by transillumination of the large intestine, were reduced by 35%. However, this reduction was not statistically significant (
P > 0.05) and differences in viability of encysted larvae were not observed. The data strongly indicated that ivermectin has little demonstrable effect on encysted equine cyathostomes.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8493773</pmid><doi>10.1016/0304-4017(93)90180-U</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals ANTHELMINTHIQUE ANTHELMINTICS ANTIHELMINTICOS Evaluation Studies as Topic Female Horse Diseases - drug therapy Horse Diseases - parasitology Horses INSPECCION POSTMORTEM IVERMECTIN Ivermectin - therapeutic use IVERMECTINA IVERMECTINE Larva - drug effects LARVAE LARVAS LARVE NECROPSIE NEMATODA PONEY PONIES POSTMORTEM EXAMINATION Strongylida - drug effects Strongylida Infections - drug therapy Strongylida Infections - parasitology Strongylida Infections - veterinary |
| title | Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae |
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