Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation
A growing literature points to a fundamental role for the ubiquitin–proteasome degradation system (UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate...
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| Veröffentlicht in: | Nature cell biology 2003-10, Vol.5 (10), p.845-850 |
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| container_title | Nature cell biology |
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| creator | Lipford, J. Russell Deshaies, Raymond J. |
| description | A growing literature points to a fundamental role for the ubiquitin–proteasome degradation system (UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate the activity of transcriptional activators. UPS might promote transcription by several mechanisms, and in some cases, even the final step of the UPS — proteolysis — might enhance activator function. |
| doi_str_mv | 10.1038/ncb1003-845 |
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| subjects | Biological research Biology Biomedical and Life Sciences Cancer Research Cell Biology Cysteine Endopeptidases - metabolism Developmental Biology Genetic aspects Life Sciences Macromolecular Substances Models, Genetic Multienzyme Complexes - metabolism perspective Physiological aspects Proteasome Endopeptidase Complex Proteins Proteolysis RNA polymerase Roles Stem Cells Transcription (Genetics) Transcription factors Transcription Factors - metabolism Transcriptional Activation Ubiquitin - metabolism Ubiquitin-proteasome system |
| title | Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation |
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