Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life
Low‐grade gliomas frequently are associated with epilepsy. The purpose of this study is to determine the impact of epilepsy and antiepileptic drug (AED) treatment on cognitive functioning and health‐related quality of life (HRQOL) in these patients. One hundred fifty‐six patients without clinical or...
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| Veröffentlicht in: | Annals of neurology 2003-10, Vol.54 (4), p.514-520 |
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| creator | Klein, Martin Engelberts, Nadine H. J. van der Ploeg, Henk M. Kasteleijn-Nolst Trenité, Dorotheé G. A. Aaronson, Neil K. Taphoorn, Martin J. B. Baaijen, Hans Vandertop, W. Peter Muller, Martin Postma, Tjeerd J. Heimans, Jan J. |
| description | Low‐grade gliomas frequently are associated with epilepsy. The purpose of this study is to determine the impact of epilepsy and antiepileptic drug (AED) treatment on cognitive functioning and health‐related quality of life (HRQOL) in these patients. One hundred fifty‐six patients without clinical or radiological signs of tumor recurrence for at least 1 year after histological diagnosis and with an epilepsy burden (based on seizure frequency and AED use) ranging from none to severe were compared with healthy controls. The association between epilepsy burden and cognition/HRQOL was also investigated. Eighty‐six percent of the patients had epilepsy and 50% of those using AEDs actually were seizure‐free. Compared with healthy controls, glioma patients had significant reductions in information processing speed, psychomotor function, attentional functioning, verbal and working memory, executive functioning, and HRQOL. The increase in epilepsy burden that was associated with significant reductions in all cognitive domains except for attentional and memory functioning could primarily be attributed to the use of AEDs, whereas the decline in HRQOL could be ascribed to the lack of complete seizure control. In conclusion, low‐grade glioma patients suffer from a number of neuropsychological and psychological problems that are aggravated by the severity of epilepsy and by the intensity of the treatment. |
| doi_str_mv | 10.1002/ana.10712 |
| format | Article |
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J. ; van der Ploeg, Henk M. ; Kasteleijn-Nolst Trenité, Dorotheé G. A. ; Aaronson, Neil K. ; Taphoorn, Martin J. B. ; Baaijen, Hans ; Vandertop, W. Peter ; Muller, Martin ; Postma, Tjeerd J. ; Heimans, Jan J.</creator><creatorcontrib>Klein, Martin ; Engelberts, Nadine H. J. ; van der Ploeg, Henk M. ; Kasteleijn-Nolst Trenité, Dorotheé G. A. ; Aaronson, Neil K. ; Taphoorn, Martin J. B. ; Baaijen, Hans ; Vandertop, W. Peter ; Muller, Martin ; Postma, Tjeerd J. ; Heimans, Jan J.</creatorcontrib><description>Low‐grade gliomas frequently are associated with epilepsy. The purpose of this study is to determine the impact of epilepsy and antiepileptic drug (AED) treatment on cognitive functioning and health‐related quality of life (HRQOL) in these patients. One hundred fifty‐six patients without clinical or radiological signs of tumor recurrence for at least 1 year after histological diagnosis and with an epilepsy burden (based on seizure frequency and AED use) ranging from none to severe were compared with healthy controls. The association between epilepsy burden and cognition/HRQOL was also investigated. Eighty‐six percent of the patients had epilepsy and 50% of those using AEDs actually were seizure‐free. Compared with healthy controls, glioma patients had significant reductions in information processing speed, psychomotor function, attentional functioning, verbal and working memory, executive functioning, and HRQOL. The increase in epilepsy burden that was associated with significant reductions in all cognitive domains except for attentional and memory functioning could primarily be attributed to the use of AEDs, whereas the decline in HRQOL could be ascribed to the lack of complete seizure control. In conclusion, low‐grade glioma patients suffer from a number of neuropsychological and psychological problems that are aggravated by the severity of epilepsy and by the intensity of the treatment.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.10712</identifier><identifier>PMID: 14520665</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Anticonvulsants - therapeutic use ; Biological and medical sciences ; Cognition - drug effects ; Decision Making ; Demography ; Epilepsy - complications ; Epilepsy - drug therapy ; Female ; Glioma - classification ; Glioma - complications ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Memory, Short-Term ; Mental Processes ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Psychometrics ; Psychomotor Performance ; Quality of Life ; Sickness Impact Profile ; Tumors of the nervous system. Phacomatoses ; Verbal Learning</subject><ispartof>Annals of neurology, 2003-10, Vol.54 (4), p.514-520</ispartof><rights>Copyright © 2003 American Neurological Association</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4552-794638614fb652317c1c21db9835e4a11a4634ed8f75733ad869a127512adda03</citedby><cites>FETCH-LOGICAL-c4552-794638614fb652317c1c21db9835e4a11a4634ed8f75733ad869a127512adda03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.10712$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.10712$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15179840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14520665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Martin</creatorcontrib><creatorcontrib>Engelberts, Nadine H. J.</creatorcontrib><creatorcontrib>van der Ploeg, Henk M.</creatorcontrib><creatorcontrib>Kasteleijn-Nolst Trenité, Dorotheé G. A.</creatorcontrib><creatorcontrib>Aaronson, Neil K.</creatorcontrib><creatorcontrib>Taphoorn, Martin J. B.</creatorcontrib><creatorcontrib>Baaijen, Hans</creatorcontrib><creatorcontrib>Vandertop, W. Peter</creatorcontrib><creatorcontrib>Muller, Martin</creatorcontrib><creatorcontrib>Postma, Tjeerd J.</creatorcontrib><creatorcontrib>Heimans, Jan J.</creatorcontrib><title>Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Low‐grade gliomas frequently are associated with epilepsy. The purpose of this study is to determine the impact of epilepsy and antiepileptic drug (AED) treatment on cognitive functioning and health‐related quality of life (HRQOL) in these patients. One hundred fifty‐six patients without clinical or radiological signs of tumor recurrence for at least 1 year after histological diagnosis and with an epilepsy burden (based on seizure frequency and AED use) ranging from none to severe were compared with healthy controls. The association between epilepsy burden and cognition/HRQOL was also investigated. Eighty‐six percent of the patients had epilepsy and 50% of those using AEDs actually were seizure‐free. Compared with healthy controls, glioma patients had significant reductions in information processing speed, psychomotor function, attentional functioning, verbal and working memory, executive functioning, and HRQOL. The increase in epilepsy burden that was associated with significant reductions in all cognitive domains except for attentional and memory functioning could primarily be attributed to the use of AEDs, whereas the decline in HRQOL could be ascribed to the lack of complete seizure control. In conclusion, low‐grade glioma patients suffer from a number of neuropsychological and psychological problems that are aggravated by the severity of epilepsy and by the intensity of the treatment.</description><subject>Adult</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cognition - drug effects</subject><subject>Decision Making</subject><subject>Demography</subject><subject>Epilepsy - complications</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Glioma - classification</subject><subject>Glioma - complications</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term</subject><subject>Mental Processes</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychometrics</subject><subject>Psychomotor Performance</subject><subject>Quality of Life</subject><subject>Sickness Impact Profile</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Verbal Learning</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCgT-AfKESh7QefybcVqEtlar20KIerVnHWQzOR-OEsv--WXahp5488jzvzOgh5AOwE2CMn2KLc2GAvyILUAKynMviNVkwoWWmQMgDcpjST8ZYoYG9JQcgFWdaqwW5PetD9H3a0NDS2D1m6wErT9cxdA2mL_Tuh6eh6dGNtGup69ZtGMNvT-updWOYv7Ct6MOEMYwb2tU0htq_I29qjMm_379H5Pv52V35Lbu6ubgsl1eZk0rxzBRSi1yDrFdacQHGgeNQrYpcKC8RAOe-9FVeG2WEwCrXBQI3CjhWFTJxRI53c_uhe5h8Gm0TkvMxYuu7KdltDIzJZ_DzDnRDl9Lga9sPocFhY4HZrUE7G7R_Dc7sx_3QadX46pncK5uBT3sAk8NYD9i6kJ45BabI5fa60x33OAvevLzRLq-X_1Znu0RIo__zP4HDL6uNMMreX19Y-bU8L2_vS1uIJywslI4</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Klein, Martin</creator><creator>Engelberts, Nadine H. J.</creator><creator>van der Ploeg, Henk M.</creator><creator>Kasteleijn-Nolst Trenité, Dorotheé G. A.</creator><creator>Aaronson, Neil K.</creator><creator>Taphoorn, Martin J. B.</creator><creator>Baaijen, Hans</creator><creator>Vandertop, W. Peter</creator><creator>Muller, Martin</creator><creator>Postma, Tjeerd J.</creator><creator>Heimans, Jan J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life</title><author>Klein, Martin ; Engelberts, Nadine H. J. ; van der Ploeg, Henk M. ; Kasteleijn-Nolst Trenité, Dorotheé G. A. ; Aaronson, Neil K. ; Taphoorn, Martin J. B. ; Baaijen, Hans ; Vandertop, W. 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Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory, Short-Term</topic><topic>Mental Processes</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Psychometrics</topic><topic>Psychomotor Performance</topic><topic>Quality of Life</topic><topic>Sickness Impact Profile</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Verbal Learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Martin</creatorcontrib><creatorcontrib>Engelberts, Nadine H. J.</creatorcontrib><creatorcontrib>van der Ploeg, Henk M.</creatorcontrib><creatorcontrib>Kasteleijn-Nolst Trenité, Dorotheé G. A.</creatorcontrib><creatorcontrib>Aaronson, Neil K.</creatorcontrib><creatorcontrib>Taphoorn, Martin J. B.</creatorcontrib><creatorcontrib>Baaijen, Hans</creatorcontrib><creatorcontrib>Vandertop, W. Peter</creatorcontrib><creatorcontrib>Muller, Martin</creatorcontrib><creatorcontrib>Postma, Tjeerd J.</creatorcontrib><creatorcontrib>Heimans, Jan J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Martin</au><au>Engelberts, Nadine H. J.</au><au>van der Ploeg, Henk M.</au><au>Kasteleijn-Nolst Trenité, Dorotheé G. A.</au><au>Aaronson, Neil K.</au><au>Taphoorn, Martin J. B.</au><au>Baaijen, Hans</au><au>Vandertop, W. Peter</au><au>Muller, Martin</au><au>Postma, Tjeerd J.</au><au>Heimans, Jan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>54</volume><issue>4</issue><spage>514</spage><epage>520</epage><pages>514-520</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Low‐grade gliomas frequently are associated with epilepsy. The purpose of this study is to determine the impact of epilepsy and antiepileptic drug (AED) treatment on cognitive functioning and health‐related quality of life (HRQOL) in these patients. One hundred fifty‐six patients without clinical or radiological signs of tumor recurrence for at least 1 year after histological diagnosis and with an epilepsy burden (based on seizure frequency and AED use) ranging from none to severe were compared with healthy controls. The association between epilepsy burden and cognition/HRQOL was also investigated. Eighty‐six percent of the patients had epilepsy and 50% of those using AEDs actually were seizure‐free. Compared with healthy controls, glioma patients had significant reductions in information processing speed, psychomotor function, attentional functioning, verbal and working memory, executive functioning, and HRQOL. The increase in epilepsy burden that was associated with significant reductions in all cognitive domains except for attentional and memory functioning could primarily be attributed to the use of AEDs, whereas the decline in HRQOL could be ascribed to the lack of complete seizure control. In conclusion, low‐grade glioma patients suffer from a number of neuropsychological and psychological problems that are aggravated by the severity of epilepsy and by the intensity of the treatment.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14520665</pmid><doi>10.1002/ana.10712</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Anticonvulsants - therapeutic use Biological and medical sciences Cognition - drug effects Decision Making Demography Epilepsy - complications Epilepsy - drug therapy Female Glioma - classification Glioma - complications Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Memory, Short-Term Mental Processes Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests Psychometrics Psychomotor Performance Quality of Life Sickness Impact Profile Tumors of the nervous system. Phacomatoses Verbal Learning |
| title | Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life |
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