A reporter for amyloid precursor protein γ-secretase activity in Drosophila

A key event in the pathogenesis of Alzheimer's disease (AD) is the deposition of senile plaques consisting largely of a peptide known as β-amyloid (Aβ) that is derived from the amyloid precursor protein (APP). A proteolytic activity called γ-secretase cleaves APP in the transmembrane domain and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2003-10, Vol.12 (20), p.2669-2678
Hauptverfasser:	Guo, Ming, Hong, Elizabeth J., Fernandes, Jolene, Zipursky, S. Larry, Hay, Bruce A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - genetics Amyloid Precursor Protein Secretases Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids Drosophila - enzymology Drosophila - genetics Drosophila - metabolism Endopeptidases - metabolism Fundamental and applied biological sciences. Psychology Genes, Reporter Genetics of eukaryotes. Biological and molecular evolution Human Microscopy, Electron, Scanning Models, Biological Models, Genetic Molecular and cellular biology Mutation Phenotype Photoreceptor Cells, Invertebrate - pathology Protein Binding Protein Structure, Tertiary Transgenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!