Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension

Patients with essential hypertension have a deficit in the endothelium-derived nitric oxide system that results in impaired endothelium-dependent vascular relaxation. The objective of this study was to determine whether this abnormality is caused by a deficiency of substrate for nitric oxide synthes...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1993-05, Vol.87 (5), p.1475-1481
Hauptverfasser:	PANZA, J. A, CASINO, P. R, BADAR, D. M, QUYYUMI, A. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adult Arginine - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Flow Velocity - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - chemistry Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Female Humans Hypertension - metabolism Hypertension - physiopathology Male Medical sciences Middle Aged Muscle Relaxation Muscle, Smooth, Vascular - physiopathology Nitric Oxide - chemistry Nitric Oxide - metabolism Nitroprusside - pharmacology Vascular Resistance - drug effects Vasodilation - drug effects
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