Contribution of tachykinin receptor subtypes to micturition reflex in guinea pigs

The aim of the present study was to determine the role of tachykinin in the micturition reflex in guinea pigs. We investigated the effects of tachykinin NK 1 receptor antagonists, GR205171 ([2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-(2 S-phenyl-piperidin-3 S-yl)-amine), CP99994 ((+), (2...

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Veröffentlicht in:	European journal of pharmacology 2003-09, Vol.477 (3), p.253-259
Hauptverfasser:	Yamamoto, Takao, Hanioka, Naomi, Maeda, Yasue, Imazumi, Katsunori, Hamada, Kaori, Matsuo, Masahiko, Manda, Toshitaka, Mutoh, Seitaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism Catheterization Central nervous system CHO Cells Cricetinae Dipeptides - administration & dosage Dipeptides - blood Dipeptides - pharmacokinetics Dose-Response Relationship, Drug Guinea Pigs - physiology Humans Indoles - administration & dosage Indoles - blood Indoles - pharmacokinetics Injections, Intravenous Iodine Radioisotopes - metabolism Male Medical sciences Micturition Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology Neurokinin-1 Receptor Antagonists Pharmacology. Drug treatments Piperidines - administration & dosage Piperidines - metabolism Piperidines - pharmacokinetics Radioligand Assay Receptors, Neurokinin-1 - physiology Spinal Cord - chemistry Spinal Cord - drug effects Spinal Cord - metabolism Substance P - antagonists & inhibitors Substance P - metabolism Succinimides - antagonists & inhibitors Succinimides - metabolism Tachykinin Tetrazoles - administration & dosage Tetrazoles - metabolism Tetrazoles - pharmacokinetics Tissue Extracts - chemistry Tissue Extracts - pharmacology Transfection - methods Urinary bladder Urinary Bladder - physiology Urination - drug effects Urination - physiology
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