Cyclin dependent kinase inhibitor p27(Kip1) is upregulated by hypoxia via an ARNT dependent pathway

Expression of cyclin dependent kinase (Cdk) inhibitor p27(Kip1), which blocks cell cycle progression from G(1) to S phase, can be regulated via multiple mechanisms including transcription, protein degradation, and translation. Recently, it was shown that p27(Kip1) plays an important role in the cell...

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Veröffentlicht in:	Journal of cellular biochemistry 2003-10, Vol.90 (3), p.548-560
Hauptverfasser:	Wang, Gang, Reisdorph, Richard, Clark, Jr, Robert E, Miskimins, Robin, Lindahl, Ronald, Miskimins, W Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Receptor Nuclear Translocator Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Hypoxia - physiology Cyclin-Dependent Kinase Inhibitor p27 DNA-Binding Proteins Gene Expression Regulation, Neoplastic - physiology Humans Mice Phosphorylation Receptors, Aryl Hydrocarbon - metabolism Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Up-Regulation - physiology
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