Generation of Allospecific Natural Killer Cells by Stimulation Across a Polymorphism of HLA-C

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were hom...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-05, Vol.260 (5111), p.1121-1124
Hauptverfasser:	Colonna, Marco, Brooks, Edward G., Falco, Michela, Ferrara, Giovan Battista, Strominger, Jack L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antigens Base Sequence Biological and medical sciences Cell Line Cell lines Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic polymorphisms Genotype Heterozygote Heterozygotes Histocompatibility antigens Histocompatibility antigens (hla, h-2 and other systems) HLA antigens HLA C antigens HLA histocompatibility antigens HLA-C Antigens - genetics HLA-C Antigens - immunology Homozygote Homozygotes Humans Isoantigens - immunology Killer cells Killer Cells, Natural - immunology Lymphocytes Mice Molecular immunology Molecular Sequence Data Natural killer cells Nucleotides Oligodeoxyribonucleotides Polymorphism, Genetic T lymphocytes
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