Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

ABSTRACT—Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive genes. Transgenic expression of a constitutively stable HIF-1α mutant increases the number of vascular vessels without vascular leakage, tissue ed...

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Veröffentlicht in:	Circulation research 2003-10, Vol.93 (7), p.664-673
Hauptverfasser:	Yamakawa, Midori, Liu, Louis X, Date, Taro, Belanger, Adam J, Vincent, Karen A, Akita, Geoffrey Y, Kuriyama, Takayuki, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - genetics Angiogenesis Inducing Agents - metabolism Angiopoietin-2 Angiopoietins Apoptosis - drug effects Biological and medical sciences Blood Vessels - drug effects Blood Vessels - growth & development Blood vessels and receptors Caspase 3 Caspases - metabolism Cell Division - drug effects Cell Hypoxia Cell Membrane Permeability - drug effects Cell Movement - drug effects Cells, Cultured Deferoxamine - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Activation - drug effects Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Genetic Vectors - administration & dosage Genetic Vectors - genetics Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Lymphokines - genetics Lymphokines - metabolism Nuclear Proteins - genetics Nuclear Proteins - physiology Placenta Growth Factor Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism Receptor, TIE-2 RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factors Vertebrates: cardiovascular system
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