Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia

Vasoactive agents were examined in arteries from control rats and rats exposed to intermittent hypoxia (10% oxygen; 8 h/day) for 3, 5 or 20 days. Hypoxic rats developed right ventricular hypertrophy after 5 days, but became pulmonary hypertensive (elevated right ventricular systolic pressure; RVSP)...

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Veröffentlicht in:	European journal of pharmacology 2003-09, Vol.477 (2), p.153-161
Hauptverfasser:	Thomas, Bronwyn J., Wanstall, Janet C.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology 5-HT (5-hydroxytryptamine, serotonin) Acetylcholine - pharmacology Animals Biological and medical sciences Endothelin-1 - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Endothelium-dependent vasodilatation Hypoxia Hypoxia - physiopathology In Vitro Techniques intermittent Ionomycin - pharmacology Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Pneumology Potassium Chloride - pharmacology Pulmonary artery Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - physiopathology Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats Rats, Wistar Serotonin - analogs & derivatives Serotonin - pharmacology Vasoactive agent Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology
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