EphB–ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion

Eph receptors and their membrane-associated ephrin ligands mediate cell–cell repulsion to guide migrating cells and axons. Repulsion requires that the ligand–receptor complex be removed from the cell surface, for example by proteolytic processing of the ephrin ectodomain. Here we show that cell cont...

Ausführliche Beschreibung