A proposed staging system for chronic myeloid leukemia

A staging system was proposed for chronic myeloid leukemia (CML) that groups patients into three stages (I, II, and III), each with two subclasses (A and B). The system uses pathologic parameters, of which the percentage of blasts in the blood and bone marrow is the most important. CML is defined as...

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Veröffentlicht in:Cancer 1993-06, Vol.71 (11), p.3788-3791
Hauptverfasser: Ross, Dennis W., Brunning, Richard D., Kantarjian, Hagop M., Phillip Koeffler, H., Ozer, Howard
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container_end_page 3791
container_issue 11
container_start_page 3788
container_title Cancer
container_volume 71
creator Ross, Dennis W.
Brunning, Richard D.
Kantarjian, Hagop M.
Phillip Koeffler, H.
Ozer, Howard
description A staging system was proposed for chronic myeloid leukemia (CML) that groups patients into three stages (I, II, and III), each with two subclasses (A and B). The system uses pathologic parameters, of which the percentage of blasts in the blood and bone marrow is the most important. CML is defined as a myeloproliferative disorder with molecular or cytogenetic evidence of the translocation of the abl oncogene on chromosome 9 to the breakpoint cluster region gene on chromosome 22. The proposed staging system is similar in format to the standard TNM system used for many solid tumors.
doi_str_mv 10.1002/1097-0142(19930601)71:11<3788::AID-CNCR2820711150>3.0.CO;2-7
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subjects Biological and medical sciences
blasts
chronic myeloid leukemia
classification
Hematologic and hematopoietic diseases
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Neoplasm Staging - methods
Prognosis
staging
title A proposed staging system for chronic myeloid leukemia
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