Effects of etomidate and hypothermia on cerebral metabolism and blood flow in a canine model of hypoperfusion

Etomidate is a nonbarbiturate hypnotic agent which, like the barbiturates, decreases the cerebral metabolic rate of oxygen consumption (CMRO2) 35-50%. The present studies assessed whether etomidate decreased CMRO2 through temperature-dependent mechanisms and whether the combination of etomidate and...

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Veröffentlicht in:	Journal of neurosurgical anesthesiology 1993-04, Vol.5 (2), p.104-110
Hauptverfasser:	Frizzell, R T, Fichtel, F M, Jordan, M B, Weprin, B E, Borchers, D J, Allen, E C, Pogue, W R, Batjer, H H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dogs Etomidate - pharmacology Female Hemodynamics - drug effects Hemodynamics - physiology Hypothermia, Induced Male Oxygen Consumption - drug effects Oxygen Consumption - physiology
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