The course of moderate amblyopia treated with patching in children: experience of the amblyopia treatment study
To * The writing committee listed in the Appendix served as author for the Pediatric Eye Disease Investigator Group. A listing of the investigators who participated in the study appears in the Appendix. assess the course of the response to patching treatment of moderate amblyopia and to assess facto...
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| description | To
*
The writing committee listed in the Appendix served as author for the Pediatric Eye Disease Investigator Group. A listing of the investigators who participated in the study appears in the Appendix.
assess the course of the response to patching treatment of moderate amblyopia and to assess factors predictive of the response in children 3 years old to younger than 7 years old.
Multicenter, randomized clinical trial comparing patching and atropine (one of the amblyopia treatment studies).
A total of 209 children 3 years old to younger than 7 years of age with amblyopia in the range of 20/40 to 20/100 from the patching treatment arm of this trial were treated with patching of the sound eye from 6 hours per day up to all waking hours. Follow-up examinations were performed at 5 weeks, 16 weeks, and 6 months. The primary outcome measure was visual acuity in the amblyopic eye at 6 months.
After 5 weeks of treatment, mean amblyopic eye acuity improved from baseline by 2.2 lines. For patients with baseline acuity of 20/80 or 20/100, a greater number of hours of prescribed patching was associated with greater improvement in the first 5 weeks (
P = .05). However, this relationship was not present when baseline acuity was 20/40 to 20/60 (
P = .57). At 6 months, visual acuity was improved from baseline by a mean of 3.1 lines, with the amount of improvement no longer related to the number of hours patching prescribed at baseline (
P = .93). Among the 157 patients improving at least 3 lines from baseline, 15% achieved their maximum improvement by 5 weeks and 52% by 16 weeks. None of the demographic or clinical factors assessed was predictive of the response to treatment.
In the treatment of moderate amblyopia, a beneficial effect of patching is present throughout the age range of 3 years old to younger than 7 years old and the acuity range of 20/40 to 20/100. At 6 months, the amount of improvement appears to be similar when 6 hours of daily patching are initially prescribed vs a greater number of hours. However, when the baseline acuity is 20/80 to 20/100, a greater number of hours of prescribed patching may improve acuity faster. |
| doi_str_mv | 10.1016/S0002-9394(03)00392-1 |
| format | Article |
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*
The writing committee listed in the Appendix served as author for the Pediatric Eye Disease Investigator Group. A listing of the investigators who participated in the study appears in the Appendix.
assess the course of the response to patching treatment of moderate amblyopia and to assess factors predictive of the response in children 3 years old to younger than 7 years old.
Multicenter, randomized clinical trial comparing patching and atropine (one of the amblyopia treatment studies).
A total of 209 children 3 years old to younger than 7 years of age with amblyopia in the range of 20/40 to 20/100 from the patching treatment arm of this trial were treated with patching of the sound eye from 6 hours per day up to all waking hours. Follow-up examinations were performed at 5 weeks, 16 weeks, and 6 months. The primary outcome measure was visual acuity in the amblyopic eye at 6 months.
After 5 weeks of treatment, mean amblyopic eye acuity improved from baseline by 2.2 lines. For patients with baseline acuity of 20/80 or 20/100, a greater number of hours of prescribed patching was associated with greater improvement in the first 5 weeks (
P = .05). However, this relationship was not present when baseline acuity was 20/40 to 20/60 (
P = .57). At 6 months, visual acuity was improved from baseline by a mean of 3.1 lines, with the amount of improvement no longer related to the number of hours patching prescribed at baseline (
P = .93). Among the 157 patients improving at least 3 lines from baseline, 15% achieved their maximum improvement by 5 weeks and 52% by 16 weeks. None of the demographic or clinical factors assessed was predictive of the response to treatment.
In the treatment of moderate amblyopia, a beneficial effect of patching is present throughout the age range of 3 years old to younger than 7 years old and the acuity range of 20/40 to 20/100. At 6 months, the amount of improvement appears to be similar when 6 hours of daily patching are initially prescribed vs a greater number of hours. However, when the baseline acuity is 20/80 to 20/100, a greater number of hours of prescribed patching may improve acuity faster.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(03)00392-1</identifier><identifier>PMID: 14516801</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age ; Amblyopia - physiopathology ; Amblyopia - therapy ; Atropine - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Compliance ; Eye ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Mydriatics - therapeutic use ; Ophthalmology ; Patients ; Pharmacology. Drug treatments ; Product introduction ; Sensory Deprivation ; Time Factors ; Treatment Outcome ; Variables ; Vision disorders ; Visual Acuity - physiology</subject><ispartof>American journal of ophthalmology, 2003-10, Vol.136 (4), p.620-629</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-ffe58de16f88262013e0bdf5a07f233472955fa275dd196d6719d893222f80203</citedby><cites>FETCH-LOGICAL-c419t-ffe58de16f88262013e0bdf5a07f233472955fa275dd196d6719d893222f80203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939403003921$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15167003$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14516801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pediatric Eye Disease Investigator Group</creatorcontrib><title>The course of moderate amblyopia treated with patching in children: experience of the amblyopia treatment study</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To
*
The writing committee listed in the Appendix served as author for the Pediatric Eye Disease Investigator Group. A listing of the investigators who participated in the study appears in the Appendix.
assess the course of the response to patching treatment of moderate amblyopia and to assess factors predictive of the response in children 3 years old to younger than 7 years old.
Multicenter, randomized clinical trial comparing patching and atropine (one of the amblyopia treatment studies).
A total of 209 children 3 years old to younger than 7 years of age with amblyopia in the range of 20/40 to 20/100 from the patching treatment arm of this trial were treated with patching of the sound eye from 6 hours per day up to all waking hours. Follow-up examinations were performed at 5 weeks, 16 weeks, and 6 months. The primary outcome measure was visual acuity in the amblyopic eye at 6 months.
After 5 weeks of treatment, mean amblyopic eye acuity improved from baseline by 2.2 lines. For patients with baseline acuity of 20/80 or 20/100, a greater number of hours of prescribed patching was associated with greater improvement in the first 5 weeks (
P = .05). However, this relationship was not present when baseline acuity was 20/40 to 20/60 (
P = .57). At 6 months, visual acuity was improved from baseline by a mean of 3.1 lines, with the amount of improvement no longer related to the number of hours patching prescribed at baseline (
P = .93). Among the 157 patients improving at least 3 lines from baseline, 15% achieved their maximum improvement by 5 weeks and 52% by 16 weeks. None of the demographic or clinical factors assessed was predictive of the response to treatment.
In the treatment of moderate amblyopia, a beneficial effect of patching is present throughout the age range of 3 years old to younger than 7 years old and the acuity range of 20/40 to 20/100. At 6 months, the amount of improvement appears to be similar when 6 hours of daily patching are initially prescribed vs a greater number of hours. However, when the baseline acuity is 20/80 to 20/100, a greater number of hours of prescribed patching may improve acuity faster.</description><subject>Age</subject><subject>Amblyopia - physiopathology</subject><subject>Amblyopia - therapy</subject><subject>Atropine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Compliance</subject><subject>Eye</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mydriatics - therapeutic use</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Product introduction</subject><subject>Sensory Deprivation</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Variables</subject><subject>Vision disorders</subject><subject>Visual Acuity - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rVDEUxYModlr9E5SAKLp4muTl46UbkaKtUHBhXYdMcuOkvC-TPHX--6YzQwu66Ormht85XM5B6AUl7ymh8sN3QghrdKv5W9K-I6TVrKGP0Ip2Sje00_QxWt0hR-g45-u6SsXVU3REuaCyI3SFpqsNYDctKQOeAh4mD8kWwHZY99tpjhaXBPXD4z-xbPBsi9vE8SeOI66P3icYTzH8nSFFGN3Oo2z-kw8wFpzL4rfP0JNg-wzPD_ME_fjy-ersorn8dv717NNl4zjVpQkBROeBytB1TDJCWyBrH4QlKrC25YppIYJlSnhPtfRSUe073TLGQkcYaU_Qm73vnKZfC-Rihpgd9L0dYVqyUUIxLqWu4Kt_wOuaxlhvM1Ry3gnNhayU2FMuTTknCGZOcbBpaygxt32YXR_mNmxDWrPrw9Cqe3lwX9YD-HvVoYAKvD4ANjvbh2RHF_M9VzFVzSr3cc9BDe13hGSy2yXuYwJXjJ_iA6fcAHpRprw</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Pediatric Eye Disease Investigator Group</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>The course of moderate amblyopia treated with patching in children: experience of the amblyopia treatment study</title></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-ffe58de16f88262013e0bdf5a07f233472955fa275dd196d6719d893222f80203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age</topic><topic>Amblyopia - physiopathology</topic><topic>Amblyopia - therapy</topic><topic>Atropine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Compliance</topic><topic>Eye</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mydriatics - therapeutic use</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Product introduction</topic><topic>Sensory Deprivation</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Variables</topic><topic>Vision disorders</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pediatric Eye Disease Investigator Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><aucorp>Pediatric Eye Disease Investigator Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The course of moderate amblyopia treated with patching in children: experience of the amblyopia treatment study</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>136</volume><issue>4</issue><spage>620</spage><epage>629</epage><pages>620-629</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To
*
The writing committee listed in the Appendix served as author for the Pediatric Eye Disease Investigator Group. A listing of the investigators who participated in the study appears in the Appendix.
assess the course of the response to patching treatment of moderate amblyopia and to assess factors predictive of the response in children 3 years old to younger than 7 years old.
Multicenter, randomized clinical trial comparing patching and atropine (one of the amblyopia treatment studies).
A total of 209 children 3 years old to younger than 7 years of age with amblyopia in the range of 20/40 to 20/100 from the patching treatment arm of this trial were treated with patching of the sound eye from 6 hours per day up to all waking hours. Follow-up examinations were performed at 5 weeks, 16 weeks, and 6 months. The primary outcome measure was visual acuity in the amblyopic eye at 6 months.
After 5 weeks of treatment, mean amblyopic eye acuity improved from baseline by 2.2 lines. For patients with baseline acuity of 20/80 or 20/100, a greater number of hours of prescribed patching was associated with greater improvement in the first 5 weeks (
P = .05). However, this relationship was not present when baseline acuity was 20/40 to 20/60 (
P = .57). At 6 months, visual acuity was improved from baseline by a mean of 3.1 lines, with the amount of improvement no longer related to the number of hours patching prescribed at baseline (
P = .93). Among the 157 patients improving at least 3 lines from baseline, 15% achieved their maximum improvement by 5 weeks and 52% by 16 weeks. None of the demographic or clinical factors assessed was predictive of the response to treatment.
In the treatment of moderate amblyopia, a beneficial effect of patching is present throughout the age range of 3 years old to younger than 7 years old and the acuity range of 20/40 to 20/100. At 6 months, the amount of improvement appears to be similar when 6 hours of daily patching are initially prescribed vs a greater number of hours. However, when the baseline acuity is 20/80 to 20/100, a greater number of hours of prescribed patching may improve acuity faster.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14516801</pmid><doi>10.1016/S0002-9394(03)00392-1</doi><tpages>10</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 2003-10, Vol.136 (4), p.620-629 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Amblyopia - physiopathology Amblyopia - therapy Atropine - therapeutic use Biological and medical sciences Child Child, Preschool Compliance Eye Female Follow-Up Studies Humans Male Medical sciences Mydriatics - therapeutic use Ophthalmology Patients Pharmacology. Drug treatments Product introduction Sensory Deprivation Time Factors Treatment Outcome Variables Vision disorders Visual Acuity - physiology |
| title | The course of moderate amblyopia treated with patching in children: experience of the amblyopia treatment study |
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