Differential requirement for CD18 in T-helper effector homing

To understand the integrin requirements of T-helper (T H ) effector subsets, we investigated the contribution of CD18 (β 2 integrin) to T H 1 and T H 2 function in vitro and in relevant disease models. CD18-deficient ( Itgb2 −/− ) T cells showed largely normal in vitro function. Compared with wild-t...

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Veröffentlicht in:Nature medicine 2003-10, Vol.9 (10), p.1281-1286
Hauptverfasser: Lee, Seung-Hyo, Prince, Joseph E, Rais, Muhammad, Kheradmand, Farrah, Shardonofsky, Felix, Lu, Huifang, Beaudet, Arthur L, Smith, C Wayne, Soong, Lynn, Corry, David B
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container_end_page 1286
container_issue 10
container_start_page 1281
container_title Nature medicine
container_volume 9
creator Lee, Seung-Hyo
Prince, Joseph E
Rais, Muhammad
Kheradmand, Farrah
Shardonofsky, Felix
Lu, Huifang
Beaudet, Arthur L
Smith, C Wayne
Soong, Lynn
Corry, David B
description To understand the integrin requirements of T-helper (T H ) effector subsets, we investigated the contribution of CD18 (β 2 integrin) to T H 1 and T H 2 function in vitro and in relevant disease models. CD18-deficient ( Itgb2 −/− ) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2 −/− mice were better able to resolve Leishmania major infection and generated a superior T H 1 immune response, as assessed from draining lymph nodes. In contrast, T H 2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of T H 1 and T H 2 cells in spleens was normal, but accumulation of T H 2 (not T H 1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for T H 2, but not T H 1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T H 2 cells.
doi_str_mv 10.1038/nm932
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subjects Animals
Biomedical and Life Sciences
Biomedicine
Bronchial Provocation Tests
Cancer Research
CD18 Antigens - genetics
CD18 Antigens - immunology
CD18 Antigens - metabolism
Chemokines
Chemotaxis - physiology
Cytokines
Disease
Disease Models, Animal
Immune response
Infections
Infectious Diseases
Inflammation
Inflammation - immunology
Interleukin-4 - immunology
Interleukin-4 - metabolism
Kinases
Leishmania major - immunology
Leishmaniasis, Cutaneous - immunology
Leukocytes
Lung - immunology
Lung - pathology
Lymph nodes
Lymphatic system
Lymphocytes
Metabolic Diseases
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Molecular Medicine
Neurosciences
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
title Differential requirement for CD18 in T-helper effector homing
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