Platelet-activating Factor Inactivation by Local Expression of Platelet-activating Factor Acetyl-Hydrolase Modifies Tumor Vascularization and Growth

Purpose: Platelet-activating factor (PAF), a phospholipid mediator of inflammation, has been recently detected on tumor cells but its effect in tumor development is largely undefined. Experimental Design: To address its potential role in tumor biology, we inhibited intratumor PAF activity by enginee...

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Veröffentlicht in:	Clinical cancer research 2003-09, Vol.9 (11), p.4214-4220
Hauptverfasser:	BIANCONE, Luigi, CANTALUPPI, Vincenzo, DEL SORBO, Lorenzo, RUSSO, Simona, TJOELKER, Larry W, CAMUSSI, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Animals Base Sequence Biological and medical sciences Cell Division - physiology Cell Line, Tumor Cell Movement - physiology Chemotaxis - physiology Dissemination DNA Primers Humans Medical sciences Melanoma, Experimental - blood supply Melanoma, Experimental - pathology Mice Neovascularization, Pathologic - prevention & control Platelet Activating Factor - antagonists & inhibitors Recombinant Proteins - metabolism RNA, Messenger - genetics Transfection Tumor cell Tumors
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