Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation
In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence of late conduction recurrences has not been systematically determined. Using a prospectively designed, multistep approach, we aimed at assessing the corr...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2003-09, Vol.108 (13), p.1599-1604 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1604 |
|---|---|
| container_issue | 13 |
| container_start_page | 1599 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 108 |
| creator | CAPPATO, Riccardo NEGRONI, Silvia PECORA, Domenico BENTIVEGNA, Stefano LUPO, Pier Paolo CAROLEI, Adriana ESPOSITO, Cristina FURLANELLO, Francesco DE AMBROGGI, Luigi |
| description | In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence of late conduction recurrences has not been systematically determined.
Using a prospectively designed, multistep approach, we aimed at assessing the correlation between acute achievement and chronic maintenance of electrical conduction block across RF lesions disconnecting the distal tract of the PV in 43 patients (52.3+/-8.2 years) with AF. Forty-one left superior (LS), 42 right superior (RS), 25 left inferior (LI), and 9 right inferior (RI) PVs were targeted during 108 EP procedures (2.6+/-0.5 per patient). Seventeen patients underwent 2 procedures, 23 patients underwent 3 procedures, and 3 patients underwent 4 procedures. During the first attempt, electrical disconnection was achieved in 112 PVs (95.7%). During a next procedure (time interval, 4.6+/-1.9 months), conduction recurrence was observed in 32 of 39 LSPVs (82.1%), 29 of 40 RSPVs (72.5%), 20 of 24 LIPVs (83.3%), and 7 of 9 RIPV (77.8%). After reablation at gap sites, a later procedure (time interval, 5.1+/-2.4 months) revealed a second recurrence in 13 of 22 LSPVs (59.1%) and 14 of 19 RSPVs (73.7%).
Conduction recurrence across disconnecting RF lesions can be observed in approximately 80% of cases 4 months after ablation. After reablation, similar recurrence rates are observed 5 months later. This high rate of late conduction recurrence may contribute significantly to AF recurrence in patients undergoing catheter ablation aiming at disconnection of multiple PVs. |
| doi_str_mv | 10.1161/01.CIR.0000091081.19465.F1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75723345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75723345</sourcerecordid><originalsourceid>FETCH-LOGICAL-c524t-8c40209a43a9b8628fc2fefad20cbb289cee56962fef93e6214d285100cbcf843</originalsourceid><addsrcrecordid>eNpdkdtu1DAQhi0EosvCKyCrEtwl-JCTuUOrLq1UCYTg2nKcMXWV2MFOWvXJeD1muyuthG98mG9-z8xPyCVnJecN_8R4ubv5UbLDUpx1vOSqaupyz1-QDa9FVVS1VC_J5hAvWinEBXmT8z1eG9nWr8kFF6qRTSU35O_3FPMMdvEPQE3OkPMEYaHR0dEsQG0Mw4rRGGgCu6YEwSJoMSvTZAYfXYI_K74-0REycpnOKWKOD78pjKicvDUjHXxGrQBHLbPQ5Q7ovI5TDCY90Qfwgca8-HWieJrN4rGMTB_9cod08ijhfJ_8iGWhwlvyypkxw7vTviW_9lc_d9fF7bevN7svt4XFOSxFZysmmDKVNKrvGtE5Kxw4Mwhm-150ygLUjWoOj0pCI3g1iK7mDMPWdZXcko9HXWwK28yLnrARwCoCxDXrtm6FlDjvLbn8D7yPawpYmxZctLVgskXo8xF6nl8Cp-fkJ-xfc6YP3mrGNXqrz97qZ2_1nmPy-9MPaz_BcE49mYnAhxNgMo7cJROsz2eu5kp0bSv_AfAGs4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212752037</pqid></control><display><type>article</type><title>Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CAPPATO, Riccardo ; NEGRONI, Silvia ; PECORA, Domenico ; BENTIVEGNA, Stefano ; LUPO, Pier Paolo ; CAROLEI, Adriana ; ESPOSITO, Cristina ; FURLANELLO, Francesco ; DE AMBROGGI, Luigi</creator><creatorcontrib>CAPPATO, Riccardo ; NEGRONI, Silvia ; PECORA, Domenico ; BENTIVEGNA, Stefano ; LUPO, Pier Paolo ; CAROLEI, Adriana ; ESPOSITO, Cristina ; FURLANELLO, Francesco ; DE AMBROGGI, Luigi</creatorcontrib><description>In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence of late conduction recurrences has not been systematically determined.
Using a prospectively designed, multistep approach, we aimed at assessing the correlation between acute achievement and chronic maintenance of electrical conduction block across RF lesions disconnecting the distal tract of the PV in 43 patients (52.3+/-8.2 years) with AF. Forty-one left superior (LS), 42 right superior (RS), 25 left inferior (LI), and 9 right inferior (RI) PVs were targeted during 108 EP procedures (2.6+/-0.5 per patient). Seventeen patients underwent 2 procedures, 23 patients underwent 3 procedures, and 3 patients underwent 4 procedures. During the first attempt, electrical disconnection was achieved in 112 PVs (95.7%). During a next procedure (time interval, 4.6+/-1.9 months), conduction recurrence was observed in 32 of 39 LSPVs (82.1%), 29 of 40 RSPVs (72.5%), 20 of 24 LIPVs (83.3%), and 7 of 9 RIPV (77.8%). After reablation at gap sites, a later procedure (time interval, 5.1+/-2.4 months) revealed a second recurrence in 13 of 22 LSPVs (59.1%) and 14 of 19 RSPVs (73.7%).
Conduction recurrence across disconnecting RF lesions can be observed in approximately 80% of cases 4 months after ablation. After reablation, similar recurrence rates are observed 5 months later. This high rate of late conduction recurrence may contribute significantly to AF recurrence in patients undergoing catheter ablation aiming at disconnection of multiple PVs.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000091081.19465.F1</identifier><identifier>PMID: 12963643</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Atrial Fibrillation - diagnosis ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Biological and medical sciences ; Catheter Ablation ; Disease-Free Survival ; Diseases of the cardiovascular system ; Electric Conductivity ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Pulmonary Veins - physiopathology ; Pulmonary Veins - surgery ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Recurrence ; Treatment Outcome</subject><ispartof>Circulation (New York, N.Y.), 2003-09, Vol.108 (13), p.1599-1604</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 30 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-8c40209a43a9b8628fc2fefad20cbb289cee56962fef93e6214d285100cbcf843</citedby><cites>FETCH-LOGICAL-c524t-8c40209a43a9b8628fc2fefad20cbb289cee56962fef93e6214d285100cbcf843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3674,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15192877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12963643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAPPATO, Riccardo</creatorcontrib><creatorcontrib>NEGRONI, Silvia</creatorcontrib><creatorcontrib>PECORA, Domenico</creatorcontrib><creatorcontrib>BENTIVEGNA, Stefano</creatorcontrib><creatorcontrib>LUPO, Pier Paolo</creatorcontrib><creatorcontrib>CAROLEI, Adriana</creatorcontrib><creatorcontrib>ESPOSITO, Cristina</creatorcontrib><creatorcontrib>FURLANELLO, Francesco</creatorcontrib><creatorcontrib>DE AMBROGGI, Luigi</creatorcontrib><title>Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence of late conduction recurrences has not been systematically determined.
Using a prospectively designed, multistep approach, we aimed at assessing the correlation between acute achievement and chronic maintenance of electrical conduction block across RF lesions disconnecting the distal tract of the PV in 43 patients (52.3+/-8.2 years) with AF. Forty-one left superior (LS), 42 right superior (RS), 25 left inferior (LI), and 9 right inferior (RI) PVs were targeted during 108 EP procedures (2.6+/-0.5 per patient). Seventeen patients underwent 2 procedures, 23 patients underwent 3 procedures, and 3 patients underwent 4 procedures. During the first attempt, electrical disconnection was achieved in 112 PVs (95.7%). During a next procedure (time interval, 4.6+/-1.9 months), conduction recurrence was observed in 32 of 39 LSPVs (82.1%), 29 of 40 RSPVs (72.5%), 20 of 24 LIPVs (83.3%), and 7 of 9 RIPV (77.8%). After reablation at gap sites, a later procedure (time interval, 5.1+/-2.4 months) revealed a second recurrence in 13 of 22 LSPVs (59.1%) and 14 of 19 RSPVs (73.7%).
Conduction recurrence across disconnecting RF lesions can be observed in approximately 80% of cases 4 months after ablation. After reablation, similar recurrence rates are observed 5 months later. This high rate of late conduction recurrence may contribute significantly to AF recurrence in patients undergoing catheter ablation aiming at disconnection of multiple PVs.</description><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biological and medical sciences</subject><subject>Catheter Ablation</subject><subject>Disease-Free Survival</subject><subject>Diseases of the cardiovascular system</subject><subject>Electric Conductivity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Pulmonary Veins - surgery</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Recurrence</subject><subject>Treatment Outcome</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQhi0EosvCKyCrEtwl-JCTuUOrLq1UCYTg2nKcMXWV2MFOWvXJeD1muyuthG98mG9-z8xPyCVnJecN_8R4ubv5UbLDUpx1vOSqaupyz1-QDa9FVVS1VC_J5hAvWinEBXmT8z1eG9nWr8kFF6qRTSU35O_3FPMMdvEPQE3OkPMEYaHR0dEsQG0Mw4rRGGgCu6YEwSJoMSvTZAYfXYI_K74-0REycpnOKWKOD78pjKicvDUjHXxGrQBHLbPQ5Q7ovI5TDCY90Qfwgca8-HWieJrN4rGMTB_9cod08ijhfJ_8iGWhwlvyypkxw7vTviW_9lc_d9fF7bevN7svt4XFOSxFZysmmDKVNKrvGtE5Kxw4Mwhm-150ygLUjWoOj0pCI3g1iK7mDMPWdZXcko9HXWwK28yLnrARwCoCxDXrtm6FlDjvLbn8D7yPawpYmxZctLVgskXo8xF6nl8Cp-fkJ-xfc6YP3mrGNXqrz97qZ2_1nmPy-9MPaz_BcE49mYnAhxNgMo7cJROsz2eu5kp0bSv_AfAGs4w</recordid><startdate>20030930</startdate><enddate>20030930</enddate><creator>CAPPATO, Riccardo</creator><creator>NEGRONI, Silvia</creator><creator>PECORA, Domenico</creator><creator>BENTIVEGNA, Stefano</creator><creator>LUPO, Pier Paolo</creator><creator>CAROLEI, Adriana</creator><creator>ESPOSITO, Cristina</creator><creator>FURLANELLO, Francesco</creator><creator>DE AMBROGGI, Luigi</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20030930</creationdate><title>Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation</title><author>CAPPATO, Riccardo ; NEGRONI, Silvia ; PECORA, Domenico ; BENTIVEGNA, Stefano ; LUPO, Pier Paolo ; CAROLEI, Adriana ; ESPOSITO, Cristina ; FURLANELLO, Francesco ; DE AMBROGGI, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-8c40209a43a9b8628fc2fefad20cbb289cee56962fef93e6214d285100cbcf843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biological and medical sciences</topic><topic>Catheter Ablation</topic><topic>Disease-Free Survival</topic><topic>Diseases of the cardiovascular system</topic><topic>Electric Conductivity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Pulmonary Veins - surgery</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Recurrence</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAPPATO, Riccardo</creatorcontrib><creatorcontrib>NEGRONI, Silvia</creatorcontrib><creatorcontrib>PECORA, Domenico</creatorcontrib><creatorcontrib>BENTIVEGNA, Stefano</creatorcontrib><creatorcontrib>LUPO, Pier Paolo</creatorcontrib><creatorcontrib>CAROLEI, Adriana</creatorcontrib><creatorcontrib>ESPOSITO, Cristina</creatorcontrib><creatorcontrib>FURLANELLO, Francesco</creatorcontrib><creatorcontrib>DE AMBROGGI, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAPPATO, Riccardo</au><au>NEGRONI, Silvia</au><au>PECORA, Domenico</au><au>BENTIVEGNA, Stefano</au><au>LUPO, Pier Paolo</au><au>CAROLEI, Adriana</au><au>ESPOSITO, Cristina</au><au>FURLANELLO, Francesco</au><au>DE AMBROGGI, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2003-09-30</date><risdate>2003</risdate><volume>108</volume><issue>13</issue><spage>1599</spage><epage>1604</epage><pages>1599-1604</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence of late conduction recurrences has not been systematically determined.
Using a prospectively designed, multistep approach, we aimed at assessing the correlation between acute achievement and chronic maintenance of electrical conduction block across RF lesions disconnecting the distal tract of the PV in 43 patients (52.3+/-8.2 years) with AF. Forty-one left superior (LS), 42 right superior (RS), 25 left inferior (LI), and 9 right inferior (RI) PVs were targeted during 108 EP procedures (2.6+/-0.5 per patient). Seventeen patients underwent 2 procedures, 23 patients underwent 3 procedures, and 3 patients underwent 4 procedures. During the first attempt, electrical disconnection was achieved in 112 PVs (95.7%). During a next procedure (time interval, 4.6+/-1.9 months), conduction recurrence was observed in 32 of 39 LSPVs (82.1%), 29 of 40 RSPVs (72.5%), 20 of 24 LIPVs (83.3%), and 7 of 9 RIPV (77.8%). After reablation at gap sites, a later procedure (time interval, 5.1+/-2.4 months) revealed a second recurrence in 13 of 22 LSPVs (59.1%) and 14 of 19 RSPVs (73.7%).
Conduction recurrence across disconnecting RF lesions can be observed in approximately 80% of cases 4 months after ablation. After reablation, similar recurrence rates are observed 5 months later. This high rate of late conduction recurrence may contribute significantly to AF recurrence in patients undergoing catheter ablation aiming at disconnection of multiple PVs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12963643</pmid><doi>10.1161/01.CIR.0000091081.19465.F1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2003-09, Vol.108 (13), p.1599-1604 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75723345 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Atrial Fibrillation - diagnosis Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Biological and medical sciences Catheter Ablation Disease-Free Survival Diseases of the cardiovascular system Electric Conductivity Female Follow-Up Studies Humans Male Medical sciences Middle Aged Pulmonary Veins - physiopathology Pulmonary Veins - surgery Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recurrence Treatment Outcome |
| title | Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T09%3A18%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prospective%20assessment%20of%20late%20conduction%20recurrence%20across%20radiofrequency%20lesions%20producing%20electrical%20disconnection%20at%20the%20pulmonary%20vein%20ostium%20in%20patients%20with%20atrial%20fibrillation&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=CAPPATO,%20Riccardo&rft.date=2003-09-30&rft.volume=108&rft.issue=13&rft.spage=1599&rft.epage=1604&rft.pages=1599-1604&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.CIR.0000091081.19465.F1&rft_dat=%3Cproquest_cross%3E75723345%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212752037&rft_id=info:pmid/12963643&rfr_iscdi=true |