Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane
The repair and regeneration of injured tissues and organs depend on the re-establishment of the blood flow needed for cellular infiltration and metabolic support. Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigate...
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| Veröffentlicht in: | Brain research 2003-10, Vol.989 (1), p.9-15 |
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| creator | Ribatti, Domenico Conconi, Maria Teresa Nico, Beatrice Baiguera, Silvia Corsi, Patrizia Parnigotto, Pier Paolo Nussdorfer, Gastone G. |
| description | The repair and regeneration of injured tissues and organs depend on the re-establishment of the blood flow needed for cellular infiltration and metabolic support. Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigated the angiogenic response induced by acellular brain scaffolds implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigations. The results show that acellular brain scaffolds are able to induce a strong angiogenic response, comparable to that of fibroblast growth factor-2 (FGF-2), a well known angiogenic cytokine. The response may be considered dependent on a direct angiogenic effect exerted by the scaffold, because no inflammatory infiltrate was detectable in CAM’s mesenchyme beneath the implant. Acellular brain scaffolds might induce the release of endogenous angiogenic factors, such as FGF-2 and vascular endothelial growth factor (VEGF) released from the extracellular matrix of the developing CAM. In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFβ1). |
| doi_str_mv | 10.1016/S0006-8993(03)03225-6 |
| format | Article |
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Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigated the angiogenic response induced by acellular brain scaffolds implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigations. The results show that acellular brain scaffolds are able to induce a strong angiogenic response, comparable to that of fibroblast growth factor-2 (FGF-2), a well known angiogenic cytokine. The response may be considered dependent on a direct angiogenic effect exerted by the scaffold, because no inflammatory infiltrate was detectable in CAM’s mesenchyme beneath the implant. Acellular brain scaffolds might induce the release of endogenous angiogenic factors, such as FGF-2 and vascular endothelial growth factor (VEGF) released from the extracellular matrix of the developing CAM. In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFβ1).</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(03)03225-6</identifier><identifier>PMID: 14519506</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Allantois - cytology ; Allantois - physiology ; Allantois - transplantation ; Angiogenesis ; Animals ; Biological and medical sciences ; Brain ; Brain - cytology ; Brain - physiology ; Brain Tissue Transplantation - physiology ; Chick Embryo ; Chorioallantoic membrane ; Chorion - cytology ; Chorion - physiology ; Chorion - transplantation ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; Neovascularization, Physiologic - physiology ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Scaffold ; Transplants ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2003-10, Vol.989 (1), p.9-15</ispartof><rights>2003 Elsevier B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-de7ce1f802b98f6c6c16ae57f6c1a647d13ad2547857f88bf38091c4ac75ba973</citedby><cites>FETCH-LOGICAL-c422t-de7ce1f802b98f6c6c16ae57f6c1a647d13ad2547857f88bf38091c4ac75ba973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899303032256$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15173278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14519506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribatti, Domenico</creatorcontrib><creatorcontrib>Conconi, Maria Teresa</creatorcontrib><creatorcontrib>Nico, Beatrice</creatorcontrib><creatorcontrib>Baiguera, Silvia</creatorcontrib><creatorcontrib>Corsi, Patrizia</creatorcontrib><creatorcontrib>Parnigotto, Pier Paolo</creatorcontrib><creatorcontrib>Nussdorfer, Gastone G.</creatorcontrib><title>Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The repair and regeneration of injured tissues and organs depend on the re-establishment of the blood flow needed for cellular infiltration and metabolic support. Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigated the angiogenic response induced by acellular brain scaffolds implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigations. The results show that acellular brain scaffolds are able to induce a strong angiogenic response, comparable to that of fibroblast growth factor-2 (FGF-2), a well known angiogenic cytokine. The response may be considered dependent on a direct angiogenic effect exerted by the scaffold, because no inflammatory infiltrate was detectable in CAM’s mesenchyme beneath the implant. Acellular brain scaffolds might induce the release of endogenous angiogenic factors, such as FGF-2 and vascular endothelial growth factor (VEGF) released from the extracellular matrix of the developing CAM. In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFβ1).</description><subject>Allantois - cytology</subject><subject>Allantois - physiology</subject><subject>Allantois - transplantation</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Brain - physiology</subject><subject>Brain Tissue Transplantation - physiology</subject><subject>Chick Embryo</subject><subject>Chorioallantoic membrane</subject><subject>Chorion - cytology</subject><subject>Chorion - physiology</subject><subject>Chorion - transplantation</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regeneration</subject><subject>Scaffold</subject><subject>Transplants</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCTwD5AqKHgD_ir1NVVVCQKvUAnC3HGW9Nk3hrJ5X23-OwK3qsZMme8TPj8fsi9I6Sz5RQ-eUnIUQ22hj-ifBzwhkTjXyBNlQr1kjWkpdo8x85Ra9L-VNDzg15hU5pK6gRRG5Qupy2MW1hih5nKLs0FcBx6hcPPe722HkYhmVwGXfZxQkX70JIQ1_wNrswVyhNc8LzHWB_F_09hrHL-1SDlGNyw-Dqde09rnk3wRt0EtxQ4O1xP0O_v339dfW9ubm9_nF1edP4lrG56UF5oEET1hkdpJeeSgdC1SN1slU95a5nolW65rTuAtfEUN86r0TnjOJn6OOh7y6nhwXKbMdY1r_UGdJSrBKKcdqaZ0FqqNSUyAqKA-hzKiVDsLscR5f3lhK7WmL_WWJXvS1ZV7XErnXvjw8s3Qj9U9XRgwp8OAKuqjuEKpOP5YkTVHGmdOUuDhxU3R4jZFt8hKkaFTP42fYpPjPKX_kCqek</recordid><startdate>20031031</startdate><enddate>20031031</enddate><creator>Ribatti, Domenico</creator><creator>Conconi, Maria Teresa</creator><creator>Nico, Beatrice</creator><creator>Baiguera, Silvia</creator><creator>Corsi, Patrizia</creator><creator>Parnigotto, Pier Paolo</creator><creator>Nussdorfer, Gastone G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20031031</creationdate><title>Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane</title><author>Ribatti, Domenico ; Conconi, Maria Teresa ; Nico, Beatrice ; Baiguera, Silvia ; Corsi, Patrizia ; Parnigotto, Pier Paolo ; Nussdorfer, Gastone G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-de7ce1f802b98f6c6c16ae57f6c1a647d13ad2547857f88bf38091c4ac75ba973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Allantois - cytology</topic><topic>Allantois - physiology</topic><topic>Allantois - transplantation</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - cytology</topic><topic>Brain - physiology</topic><topic>Brain Tissue Transplantation - physiology</topic><topic>Chick Embryo</topic><topic>Chorioallantoic membrane</topic><topic>Chorion - cytology</topic><topic>Chorion - physiology</topic><topic>Chorion - transplantation</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. 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Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigated the angiogenic response induced by acellular brain scaffolds implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigations. The results show that acellular brain scaffolds are able to induce a strong angiogenic response, comparable to that of fibroblast growth factor-2 (FGF-2), a well known angiogenic cytokine. The response may be considered dependent on a direct angiogenic effect exerted by the scaffold, because no inflammatory infiltrate was detectable in CAM’s mesenchyme beneath the implant. Acellular brain scaffolds might induce the release of endogenous angiogenic factors, such as FGF-2 and vascular endothelial growth factor (VEGF) released from the extracellular matrix of the developing CAM. 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| subjects | Allantois - cytology Allantois - physiology Allantois - transplantation Angiogenesis Animals Biological and medical sciences Brain Brain - cytology Brain - physiology Brain Tissue Transplantation - physiology Chick Embryo Chorioallantoic membrane Chorion - cytology Chorion - physiology Chorion - transplantation Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley Regeneration Scaffold Transplants Vertebrates: nervous system and sense organs |
| title | Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane |
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