Correlation of cilofungin in vivo efficacy with its activity against Aspergillus fumigatus (1,3)‐β‐d‐glucan synthase

(1,3)‐β‐d‐Glucan synthase is a cell wall synthesis enzyme that is the target of cilofungin, an antifungal agent of the lipopeptide class. Cilofungin's glucan synthase inhibitory activity, MIC, and effective dose 50% in a systemic infection mouse model tend to correlate for Candida albicans. Thi...

Ausführliche Beschreibung