Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

The U1 small nuclear ribonucleoprotein (snRNP) particle is one of the Sm class of snRNPs essential for splicing of precursor messenger RNA. Mammalian U1 snRNP contains a 165-nucleotide long RNA molecule and at least 11 proteins: the U1-specific 70K proteins A and C, and the common U snRNP proteins (...

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Veröffentlicht in:	Nature (London) 1993-05, Vol.363 (6426), p.283-286
Hauptverfasser:	Tazi, Jamal, Kornstädt, Ute, Rossi, Ferdinand, Jeanteur, Philippe, Cathala, Guy, Brunel, Claude, Lührmann, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism ATP Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics HeLa Cells Humans Molecular and cellular biology Molecular genetics Phosphorylation Phosphotransferases - metabolism Proteins Ribonucleoprotein, U1 Small Nuclear - metabolism RNA Precursors - metabolism RNA Splicing Spliceosomes - metabolism Transcription. Transcription factor. Splicing. Rna processing
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