Effect of Watson−Crick and Hoogsteen Base Pairing on the Conformational Stability of C8-Phenoxyl-2′-deoxyguanosine Adducts

Bulky DNA addition products (adducts) formed through attack at the C8 site of guanine can adopt the syn orientation about the glycosidic bond due to changes in conformational stability or hydrogen-bonding preferences directly arising from the bulky group. Indeed, the bulky substituent may improve th...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The journal of physical chemistry. B 2010-10, Vol.114 (40), p.12995-13004
Hauptverfasser:	Millen, Andrea L, Churchill, Cassandra D. M, Manderville, Richard A, Wetmore, Stacey D
Format:	Artikel
Sprache:	eng
Schlagworte:	B: Biophysical Chemistry Base Pairing Deoxyguanosine - chemistry DNA Adducts - chemistry Hydrogen Bonding Nucleic Acid Conformation Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!