Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

Dermal fibroblasts were obtained from members of a family with the long-QT syndrome and from controls and were used to generate pluripotent stem cells, which were then directed to differentiate into cardiac myocytes. The cells recapitulated characteristics of the long-QT syndrome. The long-QT syndro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2010-10, Vol.363 (15), p.1397-1409
Hauptverfasser:	Moretti, Alessandra, Bellin, Milena, Welling, Andrea, Jung, Christian Billy, Lam, Jason T, Bott-Flügel, Lorenz, Dorn, Tatjana, Goedel, Alexander, Höhnke, Christian, Hofmann, Franz, Seyfarth, Melchior, Sinnecker, Daniel, Schömig, Albert, Laugwitz, Karl-Ludwig
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Adult Aged Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Cardiotonic Agents - pharmacology Child Electrocardiography Female Fibroblasts - cytology Gene Expression General aspects Heart Humans Induced Pluripotent Stem Cells - physiology Isoproterenol - pharmacology KCNQ1 Potassium Channel - genetics Male Medical research Medical sciences Mutation Mutation, Missense Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Pedigree Phenotype Potassium Channel Blockers - pharmacology Potassium Channels - physiology Reverse Transcriptase Polymerase Chain Reaction Romano-Ward Syndrome - drug therapy Romano-Ward Syndrome - genetics Romano-Ward Syndrome - physiopathology Stem cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!