Naltrexone-induced alterations of the distribution of morphine in brain regions and spinal cord of the rat

The effects of naltrexone injected intravenously (i.v.) on the pharmacological actions and distribution of i.v. injected morphine in brain regions and spinal cord of male Sprague-Dawley rats were determined. Naltrexone (0.625- and 2.5-mg/kg doses) antagonized the analgesic and hyperthermic effects o...

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Veröffentlicht in:	Brain research 1993-04, Vol.607 (1), p.1-8
Hauptverfasser:	Bhargava, Hemendra N., Larsen, A. Karl, Rahmani, Nafasat H., Villar, Vincent M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences Body Temperature - drug effects Brain - drug effects Brain - metabolism Brain region Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Half-Life Injections, Intravenous Male Morphine - pharmacokinetics Morphine - pharmacology Morphine level Naltrexone Naltrexone - pharmacology Pain Measurement - drug effects Radioimmunoassay Rats Rats, Sprague-Dawley Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Vertebrates: nervous system and sense organs
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