Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: A role for protein kinase A

The role of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) in modulation of vascular cell proliferation is believed to be mediated, in part, by its ability to regulate the activity of certain growth factors through direct binding. In this study, we demonstrate that S...

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Veröffentlicht in:	Journal of cellular biochemistry 2003-10, Vol.90 (2), p.408-423
Hauptverfasser:	Motamed, Kouros, Blake, David J., Angello, John C., Allen, Benjamin L., Rapraeger, Alan C., Hauschka, Stephen D., Sage, E. Helene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Calcium - metabolism Cell Differentiation Cell Division Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism DNA - metabolism endothelial cell Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Fibroblast Growth Factor 2 - metabolism fibroblast growth factor receptor-1 Heparan Sulfate Proteoglycans - deficiency Humans Ligands matricellular Mice Mitogen-Activated Protein Kinases - antagonists & inhibitors Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Myeloid Cells - cytology Myeloid Cells - drug effects Myeloid Cells - metabolism Myoblasts - cytology Myoblasts - drug effects Myoblasts - metabolism Osteonectin - pharmacology Peptide Fragments - pharmacology Phosphorylation proliferation protein kinase A Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - metabolism Recombinant Proteins - metabolism Signal Transduction SPARC Swine
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