Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland
Recent molecular studies on autism and related disorders have supported a multilocus etiology for the disease spectrum. To maximize genetic and cultural homogeneity, we have focused our molecular studies to families originating from a subisolate of Central Finland. Genealogical studies enabled the i...
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| Veröffentlicht in: | Molecular psychiatry 2003-10, Vol.8 (10), p.879-884 |
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| container_title | Molecular psychiatry |
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| creator | Auranen, M Varilo, T Alen, R Vanhala, R Ayers, K Kempas, E Ylisaukko-oja, T Peltonen, L Järvelä, I |
| description | Recent molecular studies on autism and related disorders have supported a multilocus etiology for the disease spectrum. To maximize genetic and cultural homogeneity, we have focused our molecular studies to families originating from a subisolate of Central Finland. Genealogical studies enabled the identification of a megapedigree comprising of 12 core families with autism and Asperger syndrome (AS). We analyzed two chromosomal regions on Iq and 3q showing highest lod scores in our genome-wide scan, as well as the AUTS1 locus on chromosome 7q. For markers on 3q25–27, more significant association was observed in families from subisolate compared to families from the rest of Finland. In contrast, no clear evidence for association on AUTS1 locus was obtained. The wide interval showing association, in particular, on chromosome 3q suggests a locus for autism spectrum of disorders on this chromosomal region. |
| doi_str_mv | 10.1038/sj.mp.4001299 |
| format | Article |
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To maximize genetic and cultural homogeneity, we have focused our molecular studies to families originating from a subisolate of Central Finland. Genealogical studies enabled the identification of a megapedigree comprising of 12 core families with autism and Asperger syndrome (AS). We analyzed two chromosomal regions on Iq and 3q showing highest lod scores in our genome-wide scan, as well as the AUTS1 locus on chromosome 7q. For markers on 3q25–27, more significant association was observed in families from subisolate compared to families from the rest of Finland. In contrast, no clear evidence for association on AUTS1 locus was obtained. The wide interval showing association, in particular, on chromosome 3q suggests a locus for autism spectrum of disorders on this chromosomal region.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4001299</identifier><identifier>PMID: 14515138</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Asperger Syndrome - genetics ; Autism ; Autistic Disorder - genetics ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Child clinical studies ; Chromosome 3 ; Chromosome 7 ; Chromosomes ; Chromosomes, Human, Pair 3 ; Developmental disorders ; Etiology ; Family Health ; Female ; Finland ; General aspects. Genetic counseling ; Genomes ; Humans ; Infant ; Infantile autism ; Male ; Medical genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Microsatellite Repeats ; Neurosciences ; original-research-article ; Pedigree ; Pharmacotherapy ; Phenotype ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Molecular psychiatry, 2003-10, Vol.8 (10), p.879-884</ispartof><rights>Springer Nature Limited 2003</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-f362b555b6454d2701fe5571b314f2fbe8d0d5c628bc8153b11758ab154c9bf03</citedby><cites>FETCH-LOGICAL-c502t-f362b555b6454d2701fe5571b314f2fbe8d0d5c628bc8153b11758ab154c9bf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4001299$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4001299$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15218351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14515138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auranen, M</creatorcontrib><creatorcontrib>Varilo, T</creatorcontrib><creatorcontrib>Alen, R</creatorcontrib><creatorcontrib>Vanhala, R</creatorcontrib><creatorcontrib>Ayers, K</creatorcontrib><creatorcontrib>Kempas, E</creatorcontrib><creatorcontrib>Ylisaukko-oja, T</creatorcontrib><creatorcontrib>Peltonen, L</creatorcontrib><creatorcontrib>Järvelä, I</creatorcontrib><title>Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Recent molecular studies on autism and related disorders have supported a multilocus etiology for the disease spectrum. To maximize genetic and cultural homogeneity, we have focused our molecular studies to families originating from a subisolate of Central Finland. Genealogical studies enabled the identification of a megapedigree comprising of 12 core families with autism and Asperger syndrome (AS). We analyzed two chromosomal regions on Iq and 3q showing highest lod scores in our genome-wide scan, as well as the AUTS1 locus on chromosome 7q. For markers on 3q25–27, more significant association was observed in families from subisolate compared to families from the rest of Finland. In contrast, no clear evidence for association on AUTS1 locus was obtained. The wide interval showing association, in particular, on chromosome 3q suggests a locus for autism spectrum of disorders on this chromosomal region.</description><subject>Asperger Syndrome - genetics</subject><subject>Autism</subject><subject>Autistic Disorder - genetics</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Child clinical studies</subject><subject>Chromosome 3</subject><subject>Chromosome 7</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Developmental disorders</subject><subject>Etiology</subject><subject>Family Health</subject><subject>Female</subject><subject>Finland</subject><subject>General aspects. Genetic counseling</subject><subject>Genomes</subject><subject>Humans</subject><subject>Infant</subject><subject>Infantile autism</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microsatellite Repeats</subject><subject>Neurosciences</subject><subject>original-research-article</subject><subject>Pedigree</subject><subject>Pharmacotherapy</subject><subject>Phenotype</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Genetic counseling</topic><topic>Genomes</topic><topic>Humans</topic><topic>Infant</topic><topic>Infantile autism</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microsatellite Repeats</topic><topic>Neurosciences</topic><topic>original-research-article</topic><topic>Pedigree</topic><topic>Pharmacotherapy</topic><topic>Phenotype</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auranen, M</creatorcontrib><creatorcontrib>Varilo, T</creatorcontrib><creatorcontrib>Alen, R</creatorcontrib><creatorcontrib>Vanhala, R</creatorcontrib><creatorcontrib>Ayers, K</creatorcontrib><creatorcontrib>Kempas, E</creatorcontrib><creatorcontrib>Ylisaukko-oja, T</creatorcontrib><creatorcontrib>Peltonen, L</creatorcontrib><creatorcontrib>Järvelä, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auranen, M</au><au>Varilo, T</au><au>Alen, R</au><au>Vanhala, R</au><au>Ayers, K</au><au>Kempas, E</au><au>Ylisaukko-oja, T</au><au>Peltonen, L</au><au>Järvelä, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>8</volume><issue>10</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Recent molecular studies on autism and related disorders have supported a multilocus etiology for the disease spectrum. To maximize genetic and cultural homogeneity, we have focused our molecular studies to families originating from a subisolate of Central Finland. Genealogical studies enabled the identification of a megapedigree comprising of 12 core families with autism and Asperger syndrome (AS). We analyzed two chromosomal regions on Iq and 3q showing highest lod scores in our genome-wide scan, as well as the AUTS1 locus on chromosome 7q. For markers on 3q25–27, more significant association was observed in families from subisolate compared to families from the rest of Finland. In contrast, no clear evidence for association on AUTS1 locus was obtained. The wide interval showing association, in particular, on chromosome 3q suggests a locus for autism spectrum of disorders on this chromosomal region.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14515138</pmid><doi>10.1038/sj.mp.4001299</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asperger Syndrome - genetics Autism Autistic Disorder - genetics Behavioral Sciences Biological and medical sciences Biological Psychology Child clinical studies Chromosome 3 Chromosome 7 Chromosomes Chromosomes, Human, Pair 3 Developmental disorders Etiology Family Health Female Finland General aspects. Genetic counseling Genomes Humans Infant Infantile autism Male Medical genetics Medical sciences Medicine Medicine & Public Health Microsatellite Repeats Neurosciences original-research-article Pedigree Pharmacotherapy Phenotype Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland |
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