Structure-function studies of amphiphilic antibacterial peptides

The synthesis of 11 peptides, ranging in composition from 9 to 17 amino acid residues, by solid-phase methodology was accomplished with the purpose of studying how the amphiphilic and hydrophobic character, the size of the molecule, and the charge distribution modulate the antibacterial activity. It...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-04, Vol.36 (9), p.1203-1209
Hauptverfasser:	Bessalle, Roberto, Gorea, Alfred, Shalit, Itamar, Metzger, Joerg W, Dass, Chhabil, Desiderio, Dominic M, Fridkin, Mati
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteria - drug effects Cell Membrane Permeability - drug effects Chemistry Circular Dichroism Computer Simulation Diffusion Escherichia coli - drug effects Exact sciences and technology Hemolysis Humans Models, Molecular Molecular Sequence Data Molecular Weight Organic chemistry Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Preparations and properties Protein Structure, Secondary Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Structure-Activity Relationship Valinomycin - pharmacology
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