FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia
Fanconi anaemia (FA) is an inherited form of progressive pancytopenia associated with developmental defects, chromosomal instability, and cancer predisposition. At least seven distinct FA proteins function in concert to protect the genome, a key step being the activation of FANCD2 by mono‐ubiquitina...
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| Veröffentlicht in: | The Journal of pathology 2003-10, Vol.201 (2), p.198-203 |
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| creator | Hölzel, Michael van Diest, Paul J Bier, Patrick Wallisch, Michael Hoatlin, Maureen E Joenje, Hans de Winter, Johan P |
| description | Fanconi anaemia (FA) is an inherited form of progressive pancytopenia associated with developmental defects, chromosomal instability, and cancer predisposition. At least seven distinct FA proteins function in concert to protect the genome, a key step being the activation of FANCD2 by mono‐ubiquitination. This paper reports an immunohistochemical analysis of FANCD2 expression in normal human tissue. The highest expression was observed in maturing spermatocytes and fetal oocytes (consistent with a role for FANCD2 in meiosis) and in germinal centre cells of the spleen, tonsil, and lymph nodes (consistent with a role in proliferation). FANCD2 expression was also seen in tissues predisposed to cancer development in FA patients: haematopoietic cells, especially in the fetus, and squamous cell epithelia, particularly in the head and neck region and uterine cervix. FANCD2 expression was also occasionally seen in the breast and Fallopian tube epithelium, the respiratory epithelium of the trachea, and the exocrine cells of the pancreas, indicating that these tissues may also be cancer‐prone in FA. FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki‐67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/path.1450 |
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At least seven distinct FA proteins function in concert to protect the genome, a key step being the activation of FANCD2 by mono‐ubiquitination. This paper reports an immunohistochemical analysis of FANCD2 expression in normal human tissue. The highest expression was observed in maturing spermatocytes and fetal oocytes (consistent with a role for FANCD2 in meiosis) and in germinal centre cells of the spleen, tonsil, and lymph nodes (consistent with a role in proliferation). FANCD2 expression was also seen in tissues predisposed to cancer development in FA patients: haematopoietic cells, especially in the fetus, and squamous cell epithelia, particularly in the head and neck region and uterine cervix. FANCD2 expression was also occasionally seen in the breast and Fallopian tube epithelium, the respiratory epithelium of the trachea, and the exocrine cells of the pancreas, indicating that these tissues may also be cancer‐prone in FA. FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki‐67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1450</identifier><identifier>PMID: 14517836</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers, Tumor - analysis ; cancer predisposition ; Cell Division ; Cell Line, Transformed ; Diseases of red blood cells ; DNA Replication ; FANCD2 ; Fanconi anaemia ; Fanconi Anemia - pathology ; Fanconi Anemia Complementation Group D2 Protein ; Female ; Fetus - chemistry ; Germ Cells - chemistry ; Hematologic and hematopoietic diseases ; Humans ; immunohistochemistry ; Immunohistochemistry - methods ; Ki-67 Antigen - analysis ; Male ; Medical sciences ; Meiosis ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Nuclear Proteins - analysis ; Predictive Value of Tests ; protein expression ; Sensitivity and Specificity ; Stem Cells - chemistry ; Tissue Distribution ; Tumors</subject><ispartof>The Journal of pathology, 2003-10, Vol.201 (2), p.198-203</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3890-b0b016ef2e2ebe07b3a4c5d94c018adecc56b754620a6dcddbbcff0406adefd93</citedby><cites>FETCH-LOGICAL-c3890-b0b016ef2e2ebe07b3a4c5d94c018adecc56b754620a6dcddbbcff0406adefd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1450$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1450$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15155557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14517836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hölzel, Michael</creatorcontrib><creatorcontrib>van Diest, Paul J</creatorcontrib><creatorcontrib>Bier, Patrick</creatorcontrib><creatorcontrib>Wallisch, Michael</creatorcontrib><creatorcontrib>Hoatlin, Maureen E</creatorcontrib><creatorcontrib>Joenje, Hans</creatorcontrib><creatorcontrib>de Winter, Johan P</creatorcontrib><title>FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Fanconi anaemia (FA) is an inherited form of progressive pancytopenia associated with developmental defects, chromosomal instability, and cancer predisposition. At least seven distinct FA proteins function in concert to protect the genome, a key step being the activation of FANCD2 by mono‐ubiquitination. This paper reports an immunohistochemical analysis of FANCD2 expression in normal human tissue. The highest expression was observed in maturing spermatocytes and fetal oocytes (consistent with a role for FANCD2 in meiosis) and in germinal centre cells of the spleen, tonsil, and lymph nodes (consistent with a role in proliferation). FANCD2 expression was also seen in tissues predisposed to cancer development in FA patients: haematopoietic cells, especially in the fetus, and squamous cell epithelia, particularly in the head and neck region and uterine cervix. FANCD2 expression was also occasionally seen in the breast and Fallopian tube epithelium, the respiratory epithelium of the trachea, and the exocrine cells of the pancreas, indicating that these tissues may also be cancer‐prone in FA. FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki‐67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>cancer predisposition</subject><subject>Cell Division</subject><subject>Cell Line, Transformed</subject><subject>Diseases of red blood cells</subject><subject>DNA Replication</subject><subject>FANCD2</subject><subject>Fanconi anaemia</subject><subject>Fanconi Anemia - pathology</subject><subject>Fanconi Anemia Complementation Group D2 Protein</subject><subject>Female</subject><subject>Fetus - chemistry</subject><subject>Germ Cells - chemistry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meiosis</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Nuclear Proteins - analysis</subject><subject>Predictive Value of Tests</subject><subject>protein expression</subject><subject>Sensitivity and Specificity</subject><subject>Stem Cells - chemistry</subject><subject>Tissue Distribution</subject><subject>Tumors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9v1DAQxS0EokvhwBdAvlCJQ9pxEtvJcdmyu1SrglARR2viTFhD_ix2VrTfHkcb0VN9scbzezPPj7G3Ai4FQHp1wHF_KXIJz9hCQKmSsijVc7aIvTTJcqHP2KsQfgFAWUr5kp1FVugiUwvWrpe3q-uUH_wwkuu5C5zuD55CoJrHOr63riGPo-t_ckttG_jQ8P2xw56PLoQjBT7uceToiVvsLfkkinqa1OtYD73j2CN1Dl-zFw22gd7M9zn7vv50t9omuy-bz6vlLrFZUUJSQQVCUZNSShWBrjLMrazL3IIosCZrpaq0zFUKqGpb11VlmwZyULHZ1GV2zi5Oc6ORP9HgaDoXJu_Y03AMRkstZCpUBD-cQOuHEDw15uBdh_7BCDBTtGaK1kzRRvbdPPRYdVQ_knOWEXg_Axgsto2Pn3fhkZNCxqMjd3Xi_rqWHp7eaL4u77bz6uSkcGGk-_8K9L-N0pmW5sftxuyg-Li52a7Mt-wfiWahXQ</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Hölzel, Michael</creator><creator>van Diest, Paul J</creator><creator>Bier, Patrick</creator><creator>Wallisch, Michael</creator><creator>Hoatlin, Maureen E</creator><creator>Joenje, Hans</creator><creator>de Winter, Johan P</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia</title><author>Hölzel, Michael ; van Diest, Paul J ; Bier, Patrick ; Wallisch, Michael ; Hoatlin, Maureen E ; Joenje, Hans ; de Winter, Johan P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3890-b0b016ef2e2ebe07b3a4c5d94c018adecc56b754620a6dcddbbcff0406adefd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>cancer predisposition</topic><topic>Cell Division</topic><topic>Cell Line, Transformed</topic><topic>Diseases of red blood cells</topic><topic>DNA Replication</topic><topic>FANCD2</topic><topic>Fanconi anaemia</topic><topic>Fanconi Anemia - pathology</topic><topic>Fanconi Anemia Complementation Group D2 Protein</topic><topic>Female</topic><topic>Fetus - chemistry</topic><topic>Germ Cells - chemistry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Immunohistochemistry - methods</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meiosis</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Nuclear Proteins - analysis</topic><topic>Predictive Value of Tests</topic><topic>protein expression</topic><topic>Sensitivity and Specificity</topic><topic>Stem Cells - chemistry</topic><topic>Tissue Distribution</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hölzel, Michael</creatorcontrib><creatorcontrib>van Diest, Paul J</creatorcontrib><creatorcontrib>Bier, Patrick</creatorcontrib><creatorcontrib>Wallisch, Michael</creatorcontrib><creatorcontrib>Hoatlin, Maureen E</creatorcontrib><creatorcontrib>Joenje, Hans</creatorcontrib><creatorcontrib>de Winter, Johan P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hölzel, Michael</au><au>van Diest, Paul J</au><au>Bier, Patrick</au><au>Wallisch, Michael</au><au>Hoatlin, Maureen E</au><au>Joenje, Hans</au><au>de Winter, Johan P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>201</volume><issue>2</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>Fanconi anaemia (FA) is an inherited form of progressive pancytopenia associated with developmental defects, chromosomal instability, and cancer predisposition. At least seven distinct FA proteins function in concert to protect the genome, a key step being the activation of FANCD2 by mono‐ubiquitination. This paper reports an immunohistochemical analysis of FANCD2 expression in normal human tissue. The highest expression was observed in maturing spermatocytes and fetal oocytes (consistent with a role for FANCD2 in meiosis) and in germinal centre cells of the spleen, tonsil, and lymph nodes (consistent with a role in proliferation). FANCD2 expression was also seen in tissues predisposed to cancer development in FA patients: haematopoietic cells, especially in the fetus, and squamous cell epithelia, particularly in the head and neck region and uterine cervix. FANCD2 expression was also occasionally seen in the breast and Fallopian tube epithelium, the respiratory epithelium of the trachea, and the exocrine cells of the pancreas, indicating that these tissues may also be cancer‐prone in FA. FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki‐67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication. Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>14517836</pmid><doi>10.1002/path.1450</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Anemias. Hemoglobinopathies Biological and medical sciences Biomarkers - analysis Biomarkers, Tumor - analysis cancer predisposition Cell Division Cell Line, Transformed Diseases of red blood cells DNA Replication FANCD2 Fanconi anaemia Fanconi Anemia - pathology Fanconi Anemia Complementation Group D2 Protein Female Fetus - chemistry Germ Cells - chemistry Hematologic and hematopoietic diseases Humans immunohistochemistry Immunohistochemistry - methods Ki-67 Antigen - analysis Male Medical sciences Meiosis Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nuclear Proteins - analysis Predictive Value of Tests protein expression Sensitivity and Specificity Stem Cells - chemistry Tissue Distribution Tumors |
| title | FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia |
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