Involvement of multidrug resistance-associated proteins in regulating cellular levels of (−)-epigallocatechin-3-gallate and its methyl metabolites

(−)-Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, has many interesting biological activities. The uptake of EGCG and involvement of specific efflux pumps were studied in MDCKII cells transfected with hPgp, hMRP1, and hMRP2 genes. Total cell associated [ 3H]EGCG increased 7-fold...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-10, Vol.310 (1), p.222-227
Hauptverfasser:	Hong, Jungil, Lambert, Joshua D, Lee, Sung-Hack, Sinko, Patrick J, Yang, Chung S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catechin - analogs & derivatives Catechin - metabolism Cell Line Dogs Drug Resistance, Multiple Efflux EGCG MDCKII cell MRP Multidrug Resistance-Associated Proteins - antagonists & inhibitors Multidrug Resistance-Associated Proteins - physiology Pgp
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